Phase 4
Completed N=43
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine
hemorrhage · Healthy
Source: ClinicalTrials.gov NCT03621085 ↗
Enrolled (actual)
43
Serious AEs
0.0%
Results posted
Nov 2021
Primary outcomePrimary: Cumulative Stress Index — 635; 649 mmHg x minutes
◆ Published Evidence
Emerging
11citations · ~2 / year
Low-dose ketamine affects blood pressure, but not muscle sympathetic nerve activity, during progressive central hypovolemia without altering tolerance.
Summary
The purpose of this project is to test how ketamine, an analgesics currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.
Linked Publications
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Low-dose ketamine affects blood pressure, but not muscle sympathetic nerve activity, during progressive central hypovolemia without altering tolerance.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cumulative Stress Index |
635; 649 | — |
| SECONDARY Pressure Pain Tolerance |
3.3; 1.6 | — |
Eligibility Criteria
Inclusion Criteria
- 18-45 years of age
- Healthy
- Non-obese (body mass index less than 30 kg/m2)
- Body mass greater than or equal to 65 kg
Exclusion Criteria
- Subjects not in the defined age range
- Subjects who have cardiac, respiratory, neurological and/or metabolic illnesses
- Any known history of renal or hepatic insufficiency/disease
- Pregnancy or breast feeding
- Body mass less than 65 kg
- Current smokers, as well as individuals who regularly smoked within the past 3 years
- Positive urine drug screen
- Currently taking pain modifying medication(s)
Data sourced from ClinicalTrials.gov (NCT03621085) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.