Effect of a Basic Skin Care Product on the Structural Strength of the Skin

Inclusion Criteria

• Healthy volunteers and/or with stable chronic condition (e.g. controlled hypertension)
• Female,
• 65 to 85 years,
• Caucasian,
• Phototype I to III according to the Fitzpatrick classification,
• Body Mass Index between 20 and 28 kg/m2,
• Non-smoker of at least one year,
• Absence of skin diseases or scars in the skin area of interest,
• Absence of tattoos in the skin area of interest,
• Able to give written informed consent,
• Willing and able to fulfill the study requirements

Exclusion Criteria

• Known or suspected defect of healing,
• Diabetes mellitus
• Any acute or chronic pathology that may interfere with the trial conduct, from investigator point of view,
• Acute or chronic wounds in the skin area of interest,
• Any skin affection which may interfere with the trial assessment, like urticaria,, psoriasis or scar on investigational areas,
• Medical history of skin cancer,
• History or establishment of diabetes or pre-diabetes,
• Any hyper-sensibility to one of the compounds of the investigational product,
• Any regular treatment which may affect the blood coagulation and hemostasis (anticoagulant medications, NSAID, etc.) before the suction blister induction (Visit 3 and Visit 5), one NSAID to treat headache within four days is allowed
• Any physical treatment (like laser or surgery) on the arms within the last 6 months,
• Use of topical or systemic treatment on the investigational areas within the past 4 weeks (topical hyaluronan, anti-inflammatory drugs, corticoids, retinoids, vitamin C, etc.) that would interfere with assessment and/or investigational treatments,
• Allergy to band-aid or to metals (such as nickel),
• UV sessions or strong sun exposure of the arms during the study period,
• Subject who cannot be contacted easily in case of necessity,
• Current participation in any other clinical study