N/A Completed N=21 Triple-blind Prevention

Bioactive Compounds in Watermelon Modulating Oxidative Stress and Inflammation in Elders

Arterial Stiffness · Inflammation

Source: ClinicalTrials.gov NCT03626168 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2022

Primary outcomePrimary: Change From Baseline in Serum Levels of Lycopene at 4 Weeks — 7.30; 3.09 uM

Summary

Watermelon is the only food with a unique combination of amino acids and antioxidants that may reduce artery stiffness. However, only 27% of older adults meet the daily recommendation for fruit intake. Because it tastes good and is convenient and easy to consume, watermelon juice is an innovative and impactful intervention to help elders easily meet recommendations for fruit servings. If effective, this intervention would be a simple, inexpensive way to combat cardiovascular diseases (CVD). Results will advance science by providing a better understanding whether four-week consumption of 100% watermelon juice may impact measures of vascular health and inflammation in postmenopausal women.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change From Baseline in Serum Levels of Lycopene at 4 Weeks	7.30; 3.09	—
PRIMARY Change in Vascular Endothelial Function at 4 Weeks	2.85; 2.17	—
PRIMARY Change in Arterial Stiffness at 4 Weeks	-0.029; -0.188	—

Eligibility Criteria

Inclusion Criteria

Ambulatory
Female
Age 55-69 years
Body mass index 18.5 - 29.9 kg/m2 (non-obese)

Exclusion Criteria

Food allergy to watermelon
History of hypotension, chronic hypertension, chronic kidney disease, diabetes, previous cardiac events or procedures, phenylketonuria
Smoking or other tobacco use
Use of anticoagulant medications, cholesterol-lowering medications, blood-pressure medications, vasodilatory dietary supplements (garlic, fish oil), or dietary supplements containing lycopene, ascorbic acid, L-glutamine, L-arginine, or L-citrulline
Weight change > 10% in the previous year

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03626168). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.