Phase 1
N=24
A Hepatic Impairment Study for PF-04965842.
Hepatic Impairment
Bottom Line
View on ClinicalTrials.gov: NCT03626415 ↗Enrolled (actual)
24
Serious AEs
0.0%
Results posted
May 2020
Primary outcome: Primary: Maximum Observed Plasma Concentration (Cmax) for PF-04965842 — 1352; 1276; 1426 nanogram per milliliter (ng/mL)
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- PF-04965842 (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Pfizer
- Primary completion
- Apr 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximum Observed Plasma Concentration (Cmax) for PF-04965842 |
1352; 1276; 1426 | — |
| PRIMARY Area Under the Plasma Concentration-Time Curve From Time Zero Extrapolated to Infinite Time (AUCinf) for PF-04965842 |
5587; 7449; 8603 | — |
| SECONDARY Number of Participants With Treatment-Emergent Adverse Events (AEs) for PF-04965842 |
2; 3; 0; 1; 3; 0 | — |
| SECONDARY Number of Participants With Laboratory Test Abnormalities (Without Regard to Baseline Abnormality) |
4; 7; 8 | — |
| SECONDARY Number of Participants With Electrocardiogram (ECG) Findings of Potential Clinical Importance for PF-04965842 |
0; 0; 0 | — |
| SECONDARY Number of Participants With Vital Sign Findings of Potential Clinical Importance for PF-04965842 |
0; 0; 0 | — |
Summary
This is a Phase 1 non randomized, open label, single dose, parallel cohort study to investigate the effect of hepatic impairment on the PK, safety and tolerability of PF 04965842.
Eligibility Criteria
Inclusion Criteria
- Body mass index (BMI) of 17.5 to 40 kg/m2; and a total body weight >50 kg (110 pounds).
- Subjects who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures.
Additional Inclusion Criteria for subjects with hepatic impairment:
- Satisfy the criteria for Class A or Class B of the Child Pugh classification (mild: Child Pugh Scores 5 to 6 points, and moderate: Child Pugh Scores 7 to 9 points), within 14 days of investigational product administration.
- A diagnosis of hepatic dysfunction due to hepatocellular disease (and not secondary to any acute ongoing hepatocellular process) documented by medical history, physical examination, liver biopsy, hepatic ultrasound, computerized tomography scan, or magnetic resonance imaging (MRI).
Exclusion Criteria
- Subjects with clinically significant infections within the past 3 months (for example, those requiring hospitalization, or as judged by the Investigator), evidence of any infection (including influenza) within the past 7 days, history of disseminated herpes simplex infection or recurrent (>1 episode) or disseminated herpes zoster.
- Subjects with a malignancy or with a history of malignancy, with the exception of adequately treated or excised non metastatic basal cell or squamous cell cancer of the skin or cervical carcinoma in situ.
Additional exclusion criteria for subjects with hepatic impairment:
- Hepatic carcinoma or hepatorenal syndrome or limited predicted life expectancy (defined as less than 1 year).
- Subjects who have previously had a transplanted kidney, liver, or heart.
- At Screening, persistent severe, uncontrolled hypertension.
Data sourced from ClinicalTrials.gov (NCT03626415). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.