N/A
Completed N=40
Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis
Osteoarthritis, Knee
Source: ClinicalTrials.gov NCT03628508 ↗
Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Mar 2021
Primary outcomePrimary: Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System — 0.50 Nm/kg
Summary
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System |
0.50 | — |
| SECONDARY Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score |
70 | — |
| SECONDARY Tibial Torsion as Assessed by X-ray Imaging |
— | — |
| SECONDARY Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography |
— | — |
Eligibility Criteria
Inclusion Criteria
- Age between 50-80
- having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3
- having medial knee pain on most days of the month
- having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking
Exclusion Criteria
- having lateral tibiofemoral compartment osteophytes greater than the medial side.
- having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months
- having a systemic arthritic condition (e.g., rheumatoid arthritis)
- having a knee joint replacement or high tibial osteotomy in the past
- having any other muscular, joint or neurological condition influencing lower limb function
- unable to walk unaided
- having low back, hip, ankle or foot pain > 3 on numerical rating scale
- having a body mass index (BMI) >36 kg/ m2
Data sourced from ClinicalTrials.gov (NCT03628508). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.