N/A
Completed N=48
Deprescribing for Older Dialysis Patients
Kidney Failure, Chronic
Source: ClinicalTrials.gov NCT03631290 ↗
Enrolled (actual)
48
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcomePrimary: Number of Deprescribing Events — 15; 2 deprescribing events
Summary
Aim 1 of the study is to identify the elements of a deprescribing intervention that address contextual factors specific to dialysis.
Aim 2 of the study, described in this record, is to determine the feasibility of a deprescribing intervention tailored for older dialysis patients.
Older adults receiving dialysis are often prescribed multiple medications. Some of these medications are used to treat symptoms, but they also can increase the chance of significant health problems. The purpose of this study is to identify if it is feasible to reduce the use of medications that have been identified as causing an increased risk for health problems.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Deprescribing Events |
15; 2 | — |
| PRIMARY Number of Potentially Eligible Subjects |
85 | — |
| PRIMARY Proportion of Clinicians Who Found the Deprescribing Program Met Their Approval |
5 | — |
| PRIMARY Proportion of Clinicians Who Found the Deprescribing Program Fit Their Routine |
2 | — |
| PRIMARY Proportion of Clinicians Who Found the Deprescribing Program Seemed Doable |
5 | — |
| SECONDARY Number of Adverse Drug Withdrawal Events |
7 | — |
| SECONDARY Change in Functional Assessment |
1.27 | — |
| SECONDARY Change in Fall Risk Questionnaire |
-0.3 | — |
| SECONDARY Change in Patient Health Questionnaire-9 (PHQ9) |
-1.36 | — |
| SECONDARY Change in Cognitive Change Index |
-2.8 | — |
| SECONDARY Sustainability, as Measured by the Proportion of Patients Who Remained Off PIM at a Lower Dose |
4 | — |
| SECONDARY Practicality, as Measured by Average Time (in Days) Spent Awaiting Provider Response to Deprescribing Recommendation |
10; 15 | — |
| SECONDARY Practicality, as Measured by the Average Time (in Days) to Initial Patient Communication |
21 | — |
| SECONDARY Practicality, as Measured by the Average Number of Attempts to Reach the Patient |
4.3 | — |
| SECONDARY Practicality, as Measured by the Average Number of Conversations |
1.4 | — |
| SECONDARY Practicality, as Measured by the Average Length of Conversations With Patients About Deprescribing |
13.6 | — |
Eligibility Criteria
Inclusion Criteria (patients):
- an adult receiving dialysis for at least 6 months
- at least one active prescription for a potentially inappropriate medication (gabapentinoids, clonidine, alpha blockers, muscle relaxants, and Z-drugs)
Exclusion Criteria (patients):
- advanced dementia
- hospice care
- non-English speaking
Inclusion Criteria (providers):
- must be employed by Duke
- must see patients at a Duke affiliated DaVita hemodialysis (HD) clinic where Duke nephrologists serve as medical directors and rounding physicians
Exclusion Criteria (providers):
None
Data sourced from ClinicalTrials.gov (NCT03631290). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.