N/A N=301 Randomized Health Services Research

Development and Evaluation of an Electronic Health Record-based Medication Complete Communication (EMC2) Strategy

Medication Adherence

Bottom Line

View on ClinicalTrials.gov: NCT03652272 ↗

Enrolled (actual)

301

Serious AEs

0.0%

Results posted

Mar 2025

Primary outcome: Primary: Medication Specific Knowledge — 63.82; 62.80 score (0-100)

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: EMC2 (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Northwestern University
Primary completion: Sep 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY Medication Specific Knowledge	63.82; 62.80	—
SECONDARY Medication Adherence- Ask 12	22.33; 21.56	—
SECONDARY Medication Adherence - Proper Use	0.78; 0.62	—

Summary

There is a well-documented need for effective interventions that can help patients understand and safely adhere to prescribed medications, particularly those with greater potential for harm if not taken correctly. The investigators will leverage health and consumer technologies with their EHR-based Medication Complete Communication (EMC2) Strategy to: 1) inform patients about medication risks and safe use, 2) promote provider education and counseling about prescribed drugs and 3) monitor patient adherence outside of visits. The EMC2 Strategy could be feasible, sustainable, and readily available to ambulatory care practices.

Eligibility Criteria

Inclusion Criteria

Patient is age 18 and older
Patient is English speaking
Patient is primarily responsible for administering their own medication
Patient must have received a new or changed prescription for a product(s), identified by Eli Lilly and the study team, within 7 days of recruitment
Patient must have access to the internet
Patient must have a patient portal account

Exclusion Criteria

Severe, uncorrectable vision
Severe hearing impairments
Severe cognitive impairment
No access to the internet or patient portal account

Providers must meet the following eligibility criteria:

Resident, Attending Physician or Mid-level provider (NP, PA) working in the NMHC Endocrinology clinic or other study sites during study dates.

*Adults unable to consent, individuals under the age of 18, and prisoners will be excluded from this research.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03652272). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.