N/A
Completed N=20
A Proof-of-Concept Trial of a Positive Psychology Intervention for Allogeneic Stem Cell Transplant Patients
Hematologic Malignancy · Hematopoietic/Lymphoid Cancer · Blood Cancer
Source: ClinicalTrials.gov NCT03654404 ↗
Enrolled (actual)
20
Serious AEs
5.0%
Results posted
Jan 2022
Primary outcomePrimary: Feasibility of Positive Psychology (PP) Intervention — 8.0 sessions completed out of 8 sessions
Summary
The goal of this research study is to find out if a novel phone-based positive psychology intervention that focuses on improving health behaviors and positive emotions can help improve mood, health related quality of life, and overall function in patients who have just undergone hematopoietic stem cell transplantation as part of blood cancer treatment.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Feasibility of Positive Psychology (PP) Intervention |
8.0 | — |
| PRIMARY Acceptability of Exercises: Ease Score |
8.0 | — |
| PRIMARY Acceptability of Exercises: Utility Score |
8.4 | — |
| SECONDARY Changes in PANAS Scores |
35.17; 37.08 | — |
| SECONDARY Changes in LOT-R Scores |
18.75; 19.50 | — |
| SECONDARY Changes in HADS Scores |
6.58; 6.00; 5.75; 5.08 | — |
| SECONDARY Changes in FACT-BMT Scores |
107.91; 110 | — |
| SECONDARY Changes in PROMIS-PF-20 Scores |
85.67; 86.33 | — |
| SECONDARY Immediate Impact of Exercises: Optimism Score |
8.0; 8.6 | — |
| SECONDARY Immediate Impact of Exercises: Positive Affect Score |
7.9; 8.5 | — |
Eligibility Criteria
Inclusion Criteria
- Adult patients with hematologic malignancies hospitalized for allogeneic HSCT at the DFCI inpatient units who are medically stable and appropriate for study approach
- Ability to speak, read and write English
- Access to a telephone
Exclusion Criteria
- Current major depressive episode, bipolar disorder, psychosis or active substance use disorder diagnosed via the Mini International Neuropsychiatric Interview (MINI)
- Cognitive deficits impeding a study participant's ability to provide informed consent or participate adequately in the study assessed via the Brief Interview for Mental Status (BIMS)
- Medical conditions precluding interviews
Data sourced from ClinicalTrials.gov (NCT03654404). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.