N/A
Completed N=2,860
Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
Orthopedic surgery · Ventilation
Source: ClinicalTrials.gov NCT03657368 ↗
Enrolled (actual)
2,860
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcomePrimary: Time-weighted Average SaO2/FiO2 Ratio in the Postanesthesia Care Unit (PACU) — 355; 350; 353; 352 ratio — p=0.042
Summary
The objective is to determine the optimal intraoperative ventilation strategy among the chosen tidal volume and positive end-expiratory pressure (PEEP) levels, and standardize it in an enhanced recovery pathway for orthopedic surgical patients. In particular, we propose to determine which combination of intraoperative tidal volume and positive end-expiratory pressure is best for patients having elective orthopedic surgery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time-weighted Average SaO2/FiO2 Ratio in the Postanesthesia Care Unit (PACU) |
355; 350; 353; 352 | 0.042 sig |
| SECONDARY Composite of Serious Postoperative Pulmonary Complications |
34; 39; 36; 37 | 0.519 |
| SECONDARY Oxygenation in Ward, Defined as Time Weighted Average (TWA) of SaO2/FIO2 Ratio |
428; 430; 429; 429 | 0.217 |
| SECONDARY Length of Postoperative Hospital Stay by Days |
3; 3; 3; 3 | 0.143 |
Eligibility Criteria
Inclusion Criteria
- Surgery in orthopedic operating rooms 32-37
- General anesthesia with endotracheal intubation.
Exclusion Criteria
- Non-orthopedic procedures;
- Intubation before induction of anesthesia.
Data sourced from ClinicalTrials.gov (NCT03657368). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.