N/A
N=120
Motivational Interviewing and Air Cleaners for Smokers With COPD (MOVE COPD)
COPD, Chronic Obstructive Pulmonary Disease
Bottom Line
View on ClinicalTrials.gov: NCT03658538 ↗Enrolled (actual)
120
Serious AEs
5.8%
Results posted
Sep 2025
Primary outcome: Primary: Change in Quality of Life -St. George's Respiratory Questionnaire (SGRQ) — -2.9; 1.5 score on a scale — p=0.025
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Active HEPA Air Cleaner (Device); Motivational interviewing (Behavioral); Sham Air Cleaner (Device)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Aug 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Quality of Life -St. George's Respiratory Questionnaire (SGRQ) |
-2.9; 1.5 | 0.025 sig |
| PRIMARY Change in Dyspnea as Assessed by the University of California San Diego Shortness of Breath Questionnaire (SDSOBQ) |
-4.8; 1.3 | 0.061 |
| SECONDARY Change in COPD Health Status Will be Assessed by the COPD Assessment Test (CAT) |
-1.8; 1.0 | — |
| SECONDARY Change in Dyspnea (Breathlessness) as Assessed by the Modified Medical Research Council Questionnaire (mMRC) |
-0.3; 0.1 | — |
| SECONDARY Difference in the Proportion (Probability) of Health Care Utilization Due to COPD-related Exacerbations |
0.11; 0.09; 0.07; 0.19 | — |
| SECONDARY Lung Function as Assessed by the Post Forced Expiratory Volume in 1 Second (FEV1%) Predicted |
-1.2; -0.8 | — |
| SECONDARY Change in the Clinical COPD Questionnaire (CCQ) |
-0.2; -0.8 | — |
Summary
COPD is characterized by lung injury and inflammation caused by noxious particles and gases, including those emanating from cigarette smoke and air pollution. Despite the clear detrimental impact of poor air quality on respiratory outcomes, regardless of smoking status, to investigators' knowledge, there are no studied environmental interventions targeting indoor air quality to improve respiratory health of smokers, thus ignoring a potential target for harm reduction. Investigators propose a randomized controlled intervention trial to test whether targeted reductions of multiple indoor pollutants (PM, SHS and NO2) in homes of smokers with COPD will improve respiratory outcomes. Investigators have chosen a potent, multimodal intervention (active air cleaners + Motivational intervention for SHS reduction) in order to maximize the opportunity to prove that there is a health benefit to active smokers with COPD from indoor air pollution reduction.
Eligibility Criteria
Inclusion Criteria
- Age ≥ 40 years,
- Physician diagnosis of COPD,
- Global Initiative for Obstructive Lung Disease (GOLD) Stage II-IV disease with Forced Expiratory Volume (FEV1)/ Forced Vital Capacity (FVC) <70% and FEV1 (% predicted) <80%. IF FEV1/FVC <70% and FEV1 (% predicted) ≥ 80%, additional requirement will apply/will be asked: COPD Assessment Test (CAT) score ≥ 10 OR exacerbation history during the last 12 months.
- Tobacco exposure ≥ 10 pack-years
- Current smoker with an exhaled Carbon Monoxide (eCO) ≥ 7 ppm to confirm smoking status. We will employ a combination of self-report and a biochemical marker to identify former-smokers. (If no eCO performed due to COronaVIrus Disease-19 (COVID-19) pandemic safety reasons, we will rely on self-report smoking status and self-report 7-day abstinence questionnaire answers)
- No home smoking ban. IF smoking is not allowed indoor (inside participant's home) then a "home air quality assessment visit" may be done.
Exclusion Criteria
- Chronic systemic corticosteroids,
- Other chronic lung disease including asthma,
- Living in location other than home (e.g., long term care facility)
- Home owner or occupant planning to move or change residence within study period.
- Air Cleaners drop off (home visits temporary criteria due to COVID-19).
Data sourced from ClinicalTrials.gov (NCT03658538). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.