Phase 3
Completed N=90
Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery
Colorectal Surgery
Source: ClinicalTrials.gov NCT03702621 ↗
Enrolled (actual)
90
Serious AEs
0.0%
Results posted
May 2023
Primary outcomePrimary: VAS Score at 1 Hour at Rest — 5.0; 3.0 score on a scale — p=0.54
◆ Published Evidence
Emerging
7citations · ~2 / year
Liposomal bupivacaine addition versus standard bupivacaine alone for colorectal surgery: a randomized controlled trial.
Summary
The purpose of this study is to compare the difference between two different pain control methods in patients who will be having a colorectal surgery
Linked Publications
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Liposomal bupivacaine addition versus standard bupivacaine alone for colorectal surgery: a randomized controlled trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY VAS Score at 1 Hour at Rest |
5.0; 3.0 | 0.54 |
| PRIMARY VAS Score at 1 Hour With Movement |
5.0; 3.0 | 0.59 |
| PRIMARY VAS Score at 24 Hours at Rest |
4.0; 3.0 | 0.98 |
| PRIMARY VAS Score at 24 Hours With Movement |
7.0; 6.0 | 0.94 |
| PRIMARY VAS Score at 48 Hours at Rest |
3.0; 2.5 | 0.86 |
| PRIMARY VAS Score at 48 Hours With Movement |
5.0; 5.0 | 1.0 |
| PRIMARY VAS Score at 72 Hours at Rest |
2.0; 2.0 | 0.99 |
| PRIMARY VAS Score at 72 Hours With Movement |
4.0; 3.0 | 0.99 |
| SECONDARY Total Opioid Consumption at 1 Hour |
8.0; 2.0 | 0.72 |
| SECONDARY Total Opioid Consumption at 24 Hour |
54.0; 30.0 | 0.29 |
| SECONDARY Total Opioid Consumption at 48 Hour |
43.8; 15.0 | 0.46 |
| SECONDARY Total Opioid Consumption at 72 Hour |
17.5; 15.0 | 0.77 |
Eligibility Criteria
Inclusion criteria
- Patients undergoing colorectal surgery at Indiana University Hospital
- American Society of Anesthesiologists (ASA) class 1, 2, 3 or 4
- Age 18 or older, male or female
- Desires Regional anesthesia for postoperative pain control
Exclusion criteria
- Any contraindication for QL block.
- History of substance abuse in the past 6 months.
- Patients on more than 30mg morphine equivalents of opioids daily.
- Any physical, mental or medical conditions which in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery.
- Known allergy or other contraindications to the study medications (Acetaminophen, Gabapentin, Bupivacaine).
- Postoperative intubation.
- Any BMI greater than 40.0.
Data sourced from ClinicalTrials.gov (NCT03702621) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.