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N/A N=16 Basic Science

Vasopressin in Intraabdominal Pressure Elevation

Intracranial Pressure Increase · Abdominal Compartment Syndrome

Bottom Line

View on ClinicalTrials.gov: NCT03707054 ↗
Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Apr 2026
Primary outcome: Primary: Changes in Vasopressin Levels During Pneumoperitoneum and Elevated PEEP — 2.37; 45.48; 54.75; 31.57 pg/ml — p=<0.0001

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Study Arm (Diagnostic_test)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
The Cleveland Clinic
Primary completion
May 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
Changes in Vasopressin Levels During Pneumoperitoneum and Elevated PEEP		 2.37; 45.48; 54.75; 31.57 <0.0001 sig

Summary

The aim of this study is to investigate any direct correlation between increased intrathoracic pressure, intraabdominal pressure and intracranial pressure, following a controlled elevation in intraabdominal pressure and intrathoracic pressure (PEEP). The second end-point is to investigate any correlation between elevated intracranial pressure and vasopressin release, urine output and urine and serum osmolality by measuring their values at different time-points.

Eligibility Criteria

Inclusion Criteria

  • Age 18-72
  • Patients meeting NIH criteria for bariatric surgery
  • Patients undergoing laparoscopic sleeve gastrectomy

Exclusion Criteria

  • • Age below 18 years
  • American Society of Anesthesiologist (ASA) class IV or V
  • Other evident/diagnosed causes of increased IAP or increased intrathoracic pressure, except for obesity
  • Active urinary tract infection
  • Previous or concomitant neurological disease
  • Previous or concomitant ophthalmic conditions/eye surgery
  • Previous or concomitant lung diseases
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03707054). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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