The Impact of Age on Adaptive Immunity in Adults Infected With Respiratory Syncytial Virus

Inclusion Criteria

• Healthy persons aged 60 to 75 years, able to give informed consent
• Non smokers or ex-smokers with smokers with less than or equal to 5 pack years smoking history.
• Spirometry within the normal range for age and height (+/- 15%)
• FEV1/FVC >70% pre-bronchodilator

Exclusion Criteria

• Chronic respiratory disease (asthma, COPD, rhinitis, sinusitis) in adulthood
• Inhaled bronchodilator or steroid use within the last 12 months
• Habitual use of any medication or other product (prescription or over-the-counter) for symptoms of rhinitis or nasal congestion within the last 3 months
• Acute upper respiratory infection (URI or sinusitis) in the past 6 weeks
• Subjects with allergic symptoms present at baseline
• Clinically relevant abnormality on chest X-ray
• Those in close domestic contact (i.e. sharing a household with, caring for, or daily face to face contact) with children under 3 years, other elderly adults (>65 years), immunosuppressed persons, or those with chronic respiratory disease
• Subjects with known or suspected immune deficiency
• Receipt of systemic glucocorticoids (in a dose ≥ 5 mg prednisone daily or equivalent) within one month, or any other cytotoxic or immunosuppressive drug within 6 months prior to challenge
• Known IgA deficiency, immotile cilia syndrome, or Kartagener's syndrome
• History of frequent nose bleeds
• Any significant medical condition or prescribed drug deemed by the study doctor to make the participant unsuitable for the study
• Women of childbearing potential must have a negative hCG urine pregnancy test *
• Positive urine drug screen
• Women of childbearing potential will have a pregnancy test performed prior to virus inoculation to exclude pregnancy and be required to use contraception throughout the study.