Phase 2
N=106
Repeat Quadratus Lumborum Block to Reduce Opioid Need in Patients After Pancreatic Surgery
Pancreatic Carcinoma
Bottom Line
View on ClinicalTrials.gov: NCT03745794 ↗Enrolled (actual)
106
Serious AEs
18.9%
Results posted
Feb 2023
Primary outcome: Primary: Number of Participants Discharged Opioid-Free — 19; 27 Participants — p=0.17
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Best Practice (Other); Quadratus Lumborum Block (Drug); Quality-of-Life Assessment (Other); Questionnaire Administration (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- M.D. Anderson Cancer Center
- Primary completion
- Jul 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Discharged Opioid-Free |
19; 27 | 0.17 |
| SECONDARY Total Inpatient Oral Morphine Equivalents (OME) |
— | — |
| SECONDARY Hospital Cost |
— | — |
| SECONDARY Quality of Life Score Assessed by MD Anderson Symptom Inventory-Gastrointestinal (MDASI-GI) |
— | — |
| SECONDARY Pain Prescription Dosage/Size |
— | — |
| SECONDARY Percentage of Patients With Initial Discharge Prescription Dosage/Size Total OME < 200 mg |
— | — |
| SECONDARY Percentage of Patients Using Opioids |
— | — |
| SECONDARY MDASI-GI in Clinic Visits |
— | — |
| SECONDARY Percentage of Patients Using Opioids |
— | — |
| SECONDARY Total OME for First 30 Days and First 90 Days (Inpatient + Outpatient) |
— | — |
| SECONDARY Patients and Family Free of Opioid Use |
— | — |
Summary
This phase II trial studies how an additional anesthetic nerve block, called a quadratus lumborum block, works to reduce the need for opioids in patients after pancreatic surgery. Giving an additional regional anesthetic after surgery may hasten the weaning process, reduce the need for opioid medications upon discharge, and reduce the risk of opioid dependence.
Eligibility Criteria
Inclusion Criteria
- Patients undergoing elective open pancreatic resection for potentially curative intent (pancreaticoduodenectomy or distal pancreatectomy) who would otherwise be treated with QL block + IV-PCA converted to oral pain meds (non-narcotic bundle + opioid pain pill).
Exclusion Criteria
- Patients with current or past substance (drug or alcohol) abuse disorder.
- Laparoscopic or minimally invasive surgery.
Data sourced from ClinicalTrials.gov (NCT03745794). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.