N/A
N=1,027
Improving CarE for Community Acquired Pneumonia 1
Pneumonia Childhood
Bottom Line
View on ClinicalTrials.gov: NCT03760419 ↗Enrolled (actual)
1,027
Serious AEs
15.3%
Results posted
Dec 2022
Primary outcome: Primary: Exclusive Guideline-Concordant Antibiotic Therapy, First 24 Hours — 255; 284; 174; 120 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Clinical Decision Support (Behavioral)
- Age
- Pediatric, Adult · 0+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University Medical Center
- Primary completion
- Sep 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Exclusive Guideline-Concordant Antibiotic Therapy, First 24 Hours |
255; 284; 174; 120; 81; 164 | — |
| SECONDARY Exclusive Guideline-Concordant Antibiotic Prescribing, Entire Episode |
240; 261; 163; 111; 77; 150 | — |
| SECONDARY Any Guideline-Concordant Antibiotic Prescribing, First 24 Hours |
297; 358; 198; 144; 99; 214 | — |
| SECONDARY Any Guideline-Concordant Antibiotic Prescribing, Entire Episode |
305; 383; 200; 146; 105; 237 | — |
Summary
Children with pneumonia presenting to the emergency department at Monroe Carell Jr. Children's Hospital at Vanderbilt or Children's Hospital of Pittsburgh will be potentially eligible for study. During intervention periods, providers caring for enrolled children will be presented with a detailed decision support strategy that emphasizes management in accordance with national guideline recommendations. The anticipated study duration is 18 months and, as this study does not include direct contact with enrolled subjects, there is no anticipated follow up.
Eligibility Criteria
Inclusion Criteria
- Six months to <18 years of age
- Radiographic evidence of pneumonia in ED
- Provider-confirmed diagnosis of pneumonia (via Clinical Decision Support [CDS])
Exclusion Criteria
- Children with tracheostomy, cystic fibrosis, immunosuppression
- Inter-hospital transfers
- Hospitalization within preceding 7 days
- Previously enrolled within preceding 28 days
- Provider preference for any reason
Data sourced from ClinicalTrials.gov (NCT03760419). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.