N/A
N=142
Delayed Sleep Timing in Teens Study
Delayed Sleep Phase
Bottom Line
View on ClinicalTrials.gov: NCT03806296 ↗Enrolled (actual)
142
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcome: Primary: Weekday Sleep Duration - Actigraphy — 6.309; 5.866; 5.880; 5.845 Number of hours — p=0.018
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Increase morning bright light (Other); Decrease evening blue light (Other); Sleep scheduling (Behavioral); Monitor sleep, mood, and substance use (Behavioral)
- Age
- Pediatric, Adult · 16+ yrs
- Sex
- All
- Sponsor
- University of Pittsburgh
- Primary completion
- Mar 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Weekday Sleep Duration - Actigraphy |
6.309; 5.866; 5.880; 5.845; 6.554 | 0.018 sig |
| PRIMARY Circadian Timing - Dim Light Melatonin Onset |
20.707; 21.849; 21.789; 22.038; 21.194 | <0.001 sig |
| PRIMARY Circadian Alignment |
6.071; 5.798; 5.937; 5.910; 5.586 | 0.365 |
| PRIMARY Reward Motivation (Behavioral) |
32.609; 37.696; 34.448; 43.961; 34.117 | 0.234 |
| PRIMARY Behavioral Inhibition |
0.910; 0.891; 0.846; 0.861; 0.829 | 0.024 sig |
| PRIMARY Neural Correlates of Reward Anticipation |
0.040; 0.027; 0.074; 0.007; 0.030 | 0.592 |
| PRIMARY Neural Correlates of Reward Receipt |
-0.009; -0.028; -0.019; 0.009; -0.008 | 0.550 |
| PRIMARY Neural Correlates of Impulse Control |
0.047; 0.066; 0.070; 0.049; 0.054 | 0.124 |
| PRIMARY Cannabis Use |
2.167; 3.200; 2.148 | 0.42 |
| PRIMARY Alcohol Use |
0.381; 1.275; 1.325 | 0.461 |
Summary
This study will (1) comprehensively characterize the substance use disorder (SUD) risk profile associated with adolescent Delayed Sleep Phase (DSP), and (2) probe whether SUD risk is diminished by altering sleep/circadian timing.
Eligibility Criteria
Inclusion Criteria
- Age 16-19 years
- Currently in 11th or 12th grade and enrolled in a traditional high-school; or cyber school with synchronous classes (not home-schooled)
- Physically and psychiatrically healthy, as determined by instruments described below
- Provision of written informed consent and assent
Additional inclusion criterion for Experimental protocol
- Meets operational definition of delayed sleep phase (DSP; weekend bedtime ≥1 AM)
Exclusion Criteria
- Significant or unstable acute or chronic medical conditions
- Past or current bipolar disorder or psychotic disorder
- Past or current substance use disorder other than alcohol use disorder or cannabis use disorder
- Past month recreational drug use other than alcohol, cannabis, and nicotine
- Current syndromal sleep disorders other than insomnia and delayed sleep phase disorder
- Medications that interfere with sleep and/or reward function (antidepressants, and stimulants prescribed for ADHD are permitted)
- Conditions that would interfere with the MRI procedures (e.g., non-removal ferromagnetic devices)
Data sourced from ClinicalTrials.gov (NCT03806296). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.