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N/A N=58 Randomized Basic Science

Modulation of Cognitive Control Signals in Prefrontal Cortex by Rhythmic Transcranial Magnetic Stimulation

Executive Function

Bottom Line

View on ClinicalTrials.gov: NCT03828734 ↗
Enrolled (actual)
58
Serious AEs
0.0%
Results posted
Nov 2020
Primary outcome: Primary: Number of Remembered Items — 1.863; 1.754; 1.796; 1.797 number of remembered items — p=0.263

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Theta TMS (Device); Alpha TMS (Device); Arrhythmic TMS (Device)
Age
Adult · 18+ yrs
Sex
All
Sponsor
University of North Carolina, Chapel Hill
Primary completion
Nov 2019

Outcome Measures

OutcomeResultp-value
PRIMARY
Number of Remembered Items		 1.863; 1.754; 1.796; 1.797; 1.803; 1.864 0.263
PRIMARY
Amplitude of Neural Oscillations		 1.443; -0.201; 0.489; 0.241; 0.944; -0.132 <0.000001 sig
PRIMARY
Response Time		 0.728; 0.714; 0.711; 0.710; 0.720; 0.717 0.399

Summary

Purpose: In this study, the investigators will provide causal evidence for the role of alpha and theta oscillations in cognitive control. Participants: Participants must be healthy, between the ages of 18 and 35, right handed, able to provide informed consent, willing to comply with all study procedures, and be available for the duration of the study, speak and understand English. Procedures: Alpha and theta brain oscillations will be measured and then entrained using frequency specific rhythmic TMS during a retrospective cued cognitive control task.

Eligibility Criteria

Inclusion Criteria

  • Healthy
  • Between the ages of 18 and 35
  • Right handed
  • Able to provide informed consent
  • Willing to comply with all study procedures
  • Available for the duration of the study
  • Speak and understand English.

Exclusion Criteria

  • Attention Deficit Hyperactivity Disorder (currently under treatment)
  • Neurological disorders and conditions, including, but not limited to: History of epilepsy Seizures (except childhood febrile seizures) -Dementia
  • History of stroke
  • Parkinson's disease
  • Multiple sclerosis
  • Cerebral aneurysm
  • Brain tumors
  • Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment)
  • Prior brain surgery -Any brain devices/implants, including cochlear implants and aneurysm clips -Cardiac pacemaker -Any other implanted electronic device -History of current traumatic brain injury -(For females) Pregnancy or breast feeding -Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03828734). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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