N/A
Completed N=58
Modulation of Cognitive Control Signals in Prefrontal Cortex by Rhythmic Transcranial Magnetic Stimulation
Executive Function
Source: ClinicalTrials.gov NCT03828734 ↗
Enrolled (actual)
58
Serious AEs
0.0%
Results posted
Nov 2020
Primary outcomePrimary: Number of Remembered Items — 1.863; 1.754; 1.796; 1.797 number of remembered items — p=0.263
Summary
Purpose: In this study, the investigators will provide causal evidence for the role of alpha and theta oscillations in cognitive control.
Participants: Participants must be healthy, between the ages of 18 and 35, right handed, able to provide informed consent, willing to comply with all study procedures, and be available for the duration of the study, speak and understand English.
Procedures: Alpha and theta brain oscillations will be measured and then entrained using frequency specific rhythmic TMS during a retrospective cued cognitive control task.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Remembered Items |
1.863; 1.754; 1.796; 1.797; 1.803; 1.864 | 0.263 |
| PRIMARY Amplitude of Neural Oscillations |
1.443; -0.201; 0.489; 0.241; 0.944; -0.132 | <0.000001 sig |
| PRIMARY Response Time |
0.728; 0.714; 0.711; 0.710; 0.720; 0.717 | 0.399 |
Eligibility Criteria
Inclusion Criteria
- Healthy
- Between the ages of 18 and 35
- Right handed
- Able to provide informed consent
- Willing to comply with all study procedures
- Available for the duration of the study
- Speak and understand English.
Exclusion Criteria
- Attention Deficit Hyperactivity Disorder (currently under treatment)
- Neurological disorders and conditions, including, but not limited to: History of epilepsy Seizures (except childhood febrile seizures) -Dementia
- History of stroke
- Parkinson's disease
- Multiple sclerosis
- Cerebral aneurysm
- Brain tumors
- Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment)
- Prior brain surgery -Any brain devices/implants, including cochlear implants and aneurysm clips -Cardiac pacemaker -Any other implanted electronic device -History of current traumatic brain injury -(For females) Pregnancy or breast feeding -Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
Data sourced from ClinicalTrials.gov (NCT03828734). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.