N/A
Completed N=77
Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure
Source: ClinicalTrials.gov NCT03832387 ↗Enrolled (actual)
77
Serious AEs
0.0%
Results posted
May 2019
Primary outcomePrimary: Rate of Intubation — 10; 23 participants
Summary
Non-invasive mechanical ventilation (NIV) has not exhibited a reduction of reintubation after extubation failure compared to oxygen therapy. The reduction of reintubation with NIV versus oxygen therapy in patients with extubation failure was evaluated.
A clinical trial was conducted that included patients who underwent mechanical ventilation and developed acute respiratory failure after extubation. After extubation failure, thirty-three were assigned to NIV and thirty-two were assigned to oxygen therapy.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Rate of Intubation |
10; 23 | — |
| SECONDARY Rate of Tracheotomy |
6; 10 | — |
| SECONDARY Intensive Care Unit Length of Stay |
18; 26 | — |
| SECONDARY Hospital Length of Stay |
41; 44 | — |
| SECONDARY Duration of Non-invasive Mechanical Ventilation or Oxygen Therapy |
37; 10 | — |
| SECONDARY Duration of Global Mechanical Ventilation |
14; 14 | — |
| SECONDARY Rate of Intensive Care Unit Mortality |
6; 6 | — |
| SECONDARY Rate of Hospital Mortality |
14; 10 | — |
| SECONDARY Rate of 90 Days Mortality |
13; 9 | — |
| SECONDARY Rate of Ventilator Associated Pneumonia |
3; 8 | — |
| SECONDARY Rate of Urinary Tract Infection |
6; 7 | — |
| SECONDARY Rate of Bacteremia |
3; 3 | — |
Eligibility Criteria
Inclusion Criteria
- Medical and surgical ICU patients with 18 years of age or older
- First episode of mechanical ventilation for more than 24 hours
Exclusion Criteria
- Structural neurological disorder
- Acute toxic-metabolic neurological encephalopathy with neurological deficit [estimated by a Glasgow Coma Score (GCS) <14 points] at the time of weaning
- Neuromuscular disease
- Chronic obstructive pulmonary disease (COPD) receiving NIV
- Limitation of life support therapy during their admission
- Tracheostomized patients
- Spinal cord injuries
- Scheduled surgical procedure during the 48 hours following extubation
- Intensive care unit readmission
- Transfer to another centre
- Contraindication to non-invasive mechanical ventilation
Data sourced from ClinicalTrials.gov (NCT03832387). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.