Phase 1 Completed N=11 Device Feasibility

Minimally Invasive Sensing of Beta-lactam Antibiotics

Healthy Volunteers

Source: ClinicalTrials.gov NCT03847610 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2020

Primary outcomePrimary: Assessment of the Biosensors Ability to Track Phenoxymethylpenicillin Concentrations Compared to Observations Made by Microdialysis and Blood Sampling — -0.16 mg/L

Summary

This study is an in-house feasibility study of a microneedle biosensor developed within Imperial College London.

Outcome Measures

Outcome	Result	p-value
PRIMARY Assessment of the Biosensors Ability to Track Phenoxymethylpenicillin Concentrations Compared to Observations Made by Microdialysis and Blood Sampling	-0.16	—

Eligibility Criteria

Inclusion Criteria

Adult >18 years old
Healthy with no evidence of active infection
Previously received penicillin with no adverse effects

Exclusion Criteria

High risk of skin soft tissue infection or local skin and soft tissue infection near sensor site
Previous history of allergies to adhesive strips or active dermatitis
Penicillin allergy or previous adverse event whilst receiving penicillin
Anaemia on screening bloods (defined as haemoglobin <13 g/dL in males and <12 g/dL in females)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03847610). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.