Phase 4
Completed N=74
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
Pain, Postoperative · Burns
Source: ClinicalTrials.gov NCT03854344 ↗
Enrolled (actual)
74
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcomePrimary: A Measurement of Post Operative Pain Involving Skin Graft Donor Site Using Visual Analog Scale (VAS) Ranging 0-10, at 8 Hours Post-operatively — 3.14; 3.68; 3.67 score on a scale 0-10
◆ Published Evidence
Emerging
16citations · ~3 / year
Evaluation of Liposomal Bupivacaine at Split-Thickness Skin Graft Donor Sites Through a Randomized, Controlled Trial.
Summary
Donor site pain study comparing post-operative donor site pain and opioid consumption after use of Lidocaine, Liposomal Bupivicaine or regional nerve block for split thickness skin graft harvesting in patients with less than 20% TBSA burn wounds and less than %5 Deep partial or full thickness burn wounds.
Linked Publications
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Evaluation of Liposomal Bupivacaine at Split-Thickness Skin Graft Donor Sites Through a Randomized, Controlled Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY A Measurement of Post Operative Pain Involving Skin Graft Donor Site Using Visual Analog Scale (VAS) Ranging 0-10, at 8 Hours Post-operatively |
3.14; 3.68; 3.67 | — |
| SECONDARY Opioid Pain Medication Consumption up to 72 Hours Post-operatively Will be Compared Between the Subjects Who Are Given Liposomal Bupivacaine (Exparel) and Lidocaine at the Donor Sites |
36.21; 49.91; 44.59 | — |
| SECONDARY Pain Scores Over 72 Hours After Surgery |
4.88; 3.64; 3 | — |
Eligibility Criteria
Inclusion Criteria
- Spanish/English speaking
- 20% TBSA burn injury; > 5% TBSA deep partial or full thickness burn
- pregnant
- allergy to lidocaine or other local anesthetics
- burns to anterior thighs
Data sourced from ClinicalTrials.gov (NCT03854344) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.