N/A
N=100
Translational Model of Anhedonia
Anhedonia
Bottom Line
View on ClinicalTrials.gov: NCT03856177 ↗Enrolled (actual)
100
Serious AEs
0.0%
Results posted
Apr 2023
Primary outcome: Primary: Reward Positivity Component of the Event-Related Electroencephalogram — 7.29; 9.23 Microvolts — p=.071
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Emotion Induction (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of New Mexico
- Primary completion
- Jul 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Reward Positivity Component of the Event-Related Electroencephalogram |
7.29; 9.23 | .071 |
Summary
The proposed research addresses a major mental health issue (anhedonia) with a novel computationally-inspired translational technique in both humans and mice. This approach greatly increases the likelihood that a positive animal model result will be successfully translated to humans. This research plan thus offers a novel way to address the NIMH's mission of defining mechanisms of complex behaviors.
Eligibility Criteria
Inclusion Criteria
- Men or women aged 18-55
- Free from psychoactive medication for at least 2 weeks
Exclusion Criteria
- Participants unwilling or unable to give informed consent
- Presence of other known medical or psychiatric comorbidity that in the investigator's opinion would compromise participation in the study
- History of psychosis
- Not fluent in English
Data sourced from ClinicalTrials.gov (NCT03856177). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.