N/A
Completed N=32
Neuromuscular Blocking Agents in the Elderly
Elective Surgery
Source: ClinicalTrials.gov NCT03857750 ↗
Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Jun 2020
Primary outcomePrimary: Onset Time — 135; 90 seconds — p=<0.001
Summary
The number of elderly patients (>80 years) is increasing and a large proportion of these patients will require surgery and anaestheasia within the next decades.
During anaesthesia NMBAs are used to facilitate tracheal intubation, from former studies it is reported that elderly patients are more sensitive towards muscle relaxants.
It is unknown if there are differences in onset times of NMBAs between younger patients and elderly.
The aim of this study is to determine the onset time, duration of action and effect on intubating conditions for rocuronium 0.6 mg/kg in patients aged 18-40 years and in patiens >80 years. The hypothesis of this study is that rocuronium administered in elderly patients (>80 years) has a longer onset time compared to younger patients.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Onset Time |
135; 90 | <0.001 sig |
| SECONDARY Comparing Intubating Conditions in the Two Groups |
7; 7; 8; 9; 1; 0 | — |
| SECONDARY Duration of Action |
81; 53 | <0.001 sig |
Eligibility Criteria
Inclusion Criteria
- Patients > 18 years old
- Informed consent
- Scheduled for elective surgery (>1 hour) under general anaesthesia with intubation and use of rocuronium.
- American Society of Anaesthesiologists (ASA) physical status classification I to III
- Can read and understand Danish
Exclusion Criteria
- Known allergy to rocuronium
- Neuromuscular disease that may interfere with neuromuscular data
- Indication for rapid sequence induction
Data sourced from ClinicalTrials.gov (NCT03857750). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.