N/A N=32

Neuromuscular Blocking Agents in the Elderly

Elective Surgery

Bottom Line

View on ClinicalTrials.gov: NCT03857750 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2020

Primary outcome: Primary: Onset Time — 135; 90 seconds — p=<0.001

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: Rocuronium (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Rigshospitalet, Denmark
Primary completion: Oct 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Onset Time	135; 90	<0.001 sig
SECONDARY Comparing Intubating Conditions in the Two Groups	7; 7; 8; 9; 1; 0	—
SECONDARY Duration of Action	81; 53	<0.001 sig

Summary

The number of elderly patients (>80 years) is increasing and a large proportion of these patients will require surgery and anaestheasia within the next decades. During anaesthesia NMBAs are used to facilitate tracheal intubation, from former studies it is reported that elderly patients are more sensitive towards muscle relaxants. It is unknown if there are differences in onset times of NMBAs between younger patients and elderly. The aim of this study is to determine the onset time, duration of action and effect on intubating conditions for rocuronium 0.6 mg/kg in patients aged 18-40 years and in patiens >80 years. The hypothesis of this study is that rocuronium administered in elderly patients (>80 years) has a longer onset time compared to younger patients.

Eligibility Criteria

Inclusion Criteria

Patients > 18 years old
Informed consent
Scheduled for elective surgery (>1 hour) under general anaesthesia with intubation and use of rocuronium.
American Society of Anaesthesiologists (ASA) physical status classification I to III
Can read and understand Danish

Exclusion Criteria

Known allergy to rocuronium
Neuromuscular disease that may interfere with neuromuscular data
Indication for rapid sequence induction

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03857750). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.