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Phase 4 N=581 Prevention

Chemoprophylaxis Plus Early Ambulation

Pulmonary Embolism · Thoracic Surgery

Enrolled (actual)
581
Serious AEs
0.0%
Results posted
Nov 2021
Primary outcome: Primary: Incidence of Postoperative Pulmonary Embolism (PE) in Surgical Thoracic Patients Under Currently Used PE Prevention Strategies. — 3 Participants

Study Design & Population

Study type
Interventional
Phase
Phase 4
Interventions
Chemoprophylaxis with Low Molecular Weight Heparin (LMWH) (Drug)
Age
Pediatric, Adult, Older Adult · 14+ yrs
Sex
All
Sponsor
Shen Lei
Primary completion
Sep 2017

Outcome Measures

OutcomeResultp-value
PRIMARY
Incidence of Postoperative Pulmonary Embolism (PE) in Surgical Thoracic Patients Under Currently Used PE Prevention Strategies.
3
SECONDARY
Provider Adherence in Implementation of PE Prevention Strategies.
306; 275

Summary

Pulmonary embolism (PE) can be a devastating postoperative complication and the leading cause of mortality after thoracic surgery. PE together with deep venous thrombosis (DVT) is called venous thromboembolism (VTE), whereas PE caused much more serious situation than DVT. Huge amount of data have demonstrated that thromboprophylaxis after surgery is very important to prevent postoperative VTE, especially after orthopedic surgery and plaster surgery. Moreover, for thoracic surgery, American College of Chest Physicians (ACCP) has published prevention guidelines of VTE in non-orthopedic surgical patients and has been used widely, but unfortunately prophylaxis measures had often been underused in China. However, to be honest, there could be a big difference between Chinese and western populations, for example, what guidelines recommended thrombolysis therapy in diagnosed massive or sub-massive PE patients is tissue type plasminogen activator (t-PA) 100 mg, while in China 50 mg has the same effect. So investigators wanted to establish if the prophylaxis measures what they were using currently are suitable for Chinese thoracic surgical patients.

Eligibility Criteria

Inclusion Criteria

  • Lung surgical patients who were sent to thoracic postoperative intensive care unit (ICU) ward right after surgery and stayed in ICU for at least 24 hours.

Exclusion Criteria

  • Cases received inferior vena filter and anti-coagulation treatment history.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03862755). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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