N/A N=201 Randomized Single-blind Other

Opiates Prescribing for Knee Arthroscopies and ACL Reconstruction

Knee Injuries · ACL Injury

Bottom Line

View on ClinicalTrials.gov: NCT03876743 ↗

Enrolled (actual)

201

Serious AEs

0.0%

Results posted

Sep 2020

Primary outcome: Primary: Numeric Pain Rating Scale (NPRS) Pain Score — 5.2; 5.3; 5.0; 5.6 score on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Group 1-Knee Arthroscopy (Other); Group 2-Knee Arthroscopy (Other); Group 1-ACL reconstruction (Other); Group 2-ACL reconstruction (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Northwestern University
Primary completion: Mar 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Numeric Pain Rating Scale (NPRS) Pain Score	5.2; 5.3; 5.0; 5.6	—
PRIMARY Opiate Count	3.5; 4.5; 9.5; 12.2	—
PRIMARY Side Effects, 24 Hours Post-op	7; 5; 23; 24	—
PRIMARY Numeric Pain Rating Scale (NPRS) Pain Scores	2.0; 2.4; 2.9; 2.6	—
PRIMARY Opiate Count	3.5; 4.5; 9.5; 12.2	—
PRIMARY Side Effects	7; 5; 24; 25	—
PRIMARY Numeric Pain Rating Scale (NPRS) Pain Scores	2.0; 2.4; 2.9; 2.6	—
PRIMARY Opiate Count	3.5; 4.5; 9.5; 12.2	—
PRIMARY Number of Participants With Side Effects	7; 5; 24; 25	—
PRIMARY Refill Requests	1; 0; 5; 7	—
PRIMARY Still Taking Opiates?	3; 0; 5; 5; 45; 47	—
PRIMARY Still Taking Opiates?	3; 0; 5; 5; 45; 47	—
PRIMARY Still Taking Opiates?	3; 0; 5; 5; 45; 47	—
PRIMARY Still Taking Opiates?	3; 0; 5; 5; 45; 47	—

Summary

The purpose of the study is to determine if opiates are required to achieve adequate analgesia after knee arthroscopy and ACL reconstruction in outpatient surgery. The investigators hypothesize that patients are frequently prescribed more opiates than are needed after surgery, resulting in excess medications that are at risk for misuse, diversion and contribution to the opioid epidemic.

Eligibility Criteria

Inclusion Criteria

All patients presenting to Northwestern Memorial Hospital (NMH) or to a Northwestern orthopaedic surgery faculty member's clinic undergoing knee arthroscopy with meniscus repair and/or debridement
18 years old or greater
Ability to read and speak English

Exclusion Criteria

Revision surgery
Oncologic surgery
Arthroscopic knee surgery that involves procedures other than ACL or the meniscus (i.e PCL, LCL, MPFL)
Patients currently taking narcotics, chronic pain management patients, history of substance abuse
Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Pregnant women
Prisoners
Patients currently taking narcotics, chronic pain management patients, history of substance abuse

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03876743). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.