N/A
N=32
Does Sound Conditioning Protect Against Temporary Hearing Damage
Hearing Loss, Noise-Induced
Bottom Line
View on ClinicalTrials.gov: NCT03878875 ↗Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcome: Primary: PTA (EF) — 7.06; 8.94; 7.94; 12.19 dB HL — p=< 0.0005
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Session One Test Battery (Diagnostic_test); Session Two Test Battery (Diagnostic_test); Session Three Test Battery (Diagnostic_test)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Imperial College Healthcare NHS Trust
- Primary completion
- Apr 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PTA (EF) |
7.06; 8.94; 7.94; 12.19 | < 0.0005 sig |
| PRIMARY DPOAE (DP) |
1.25; -0.06; 1.75; -0.88 | < 0.0005 sig |
| PRIMARY DPOAE (SNR) |
12.94; 11.63; 13.13; 11.19 | < 0.0005 sig |
| PRIMARY MEMR |
88.91; 88.44; 91.25; 90.31 | < 0.001 sig |
| PRIMARY SiN |
2.38; 2.94; 1.38; 2.44 | < 0.001 sig |
| PRIMARY Tinnitus |
5; 1; 5; 7 | < 0.005 sig |
Summary
This research project will contribute to the research surrounding the effect on the ear after noise exposure. This ever-growing field of research has never been more applicable than now with the increase of recreational noise exposure. Noise is the leading cause of preventable hearing loss and excessive occupational noise along with recreational noise exposure can cause a devastating disability. The World Health Organisation (WHO) estimates 1.1 billion young people could be at risk of hearing loss due to unsafe listening practices.
One of the mechanisms that could increase the resistance against noise induced hearing loss is 'sound conditioning'. Animal studies have found that prior exposure to low level noise over a period of a few weeks can 'condition' the ear. This conditioning then reduces the susceptibility to high level exposure i.e. strengthening the ear. In this study, the investigators aim to determine whether previous exposure to loud noise can condition the human ear, reducing the temporary hearing loss and temporary tinnitus ("ringing in the ear") that sometimes occurs after attending a loud nightclub or live music event.
There are many implications of this research. The long-term effects of non-damaging lifetime noise exposures are unclear. Principally, this research will allow better understanding about noise susceptibility and resistance, allowing for appropriate interventions, thus improving care. For instance, an individual more susceptible due to low prior exposure can be advised of risks and encouraged to use hearing protection. This thesis will increase the knowledge base surrounding the impacts of noise on hearing and educate others in understanding these.
Eligibility Criteria
Inclusion Criteria
- 18-35 years old (as age can affect cochlea hair cell function)
- Healthy participants with no significant medical conditions
- 0.25 Hz to 8 kHz PTA 20 dB HL in either ear
- Not involved in current research or have recently been involved in any research prior to recruitment
Data sourced from ClinicalTrials.gov (NCT03878875). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.