N/A N=54 Randomized Single-blind Basic Science

Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults

Cardiovascular Risk Factor · Cardiovascular Diseases · Diabetes · Physical Activity · Sedentary Lifestyle

Bottom Line

View on ClinicalTrials.gov: NCT03898206 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2026

Primary outcome: Primary: Postprandial Glucose — 1.46; 1.43; 1.74; 1.53 mmol.L-1.5 h-1

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Breaking up sitting with walking breaks (INT-SIT) (Other); Prolonged sitting (SIT) (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Bedfordshire
Primary completion: Mar 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Postprandial Glucose	1.46; 1.43; 1.74; 1.53	—
SECONDARY Postprandial Triglycerides	0.35; 0.23; 0.67; 0.63	—
SECONDARY Postprandial Insulin	24.69; 26.95; 44.19; 41.12	—
SECONDARY Metabolic Load Index	1.76; 1.60; 2.39; 2.17	—
SECONDARY Resting Energy Expenditure	0.22; 0.21; 0.18; 0.23	—
SECONDARY Resting Fat Oxidation	3.21; 0.67; 2.42; 2.12	—
SECONDARY Resting Carbohydrate Oxidation	44.28; 54.75; 43.57; 52.38	—
SECONDARY Mean Arterial Pressure	89.17; 87.24; 94.22; 93.33	—
SECONDARY Heart Rate	67.50; 67.62; 69.24; 69.76	—

Summary

The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal-weight versus overweight/obese South Asian adults.

Eligibility Criteria

Inclusion Criteria

Self-identified South Asian ethnicity.
Self-report sitting at least 7 hours per day.
Normal weight, overweight or obese.

Exclusion Criteria

Unable to speak and read English.
Contraindications to performing light-intensity walking.
Diagnosed cardiovascular disease or diabetes.

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Data sourced from ClinicalTrials.gov (NCT03898206). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.