Post Marketing Study to Evaluate the NIMBUS Device

Inclusion Criteria

• Age ≥ 18
• The subject or the subject's legally authorized representative has signed and dated an Informed Consent Form.
• Patient has had one or two passes of another mechanical thrombectomy device without achieving mTICI 2b or better and continues to have angiographic confirmation of a Large Vessel Occlusion (LVO) in the same vessel.
• mRS 0-1 prior to this stroke.
• NIMBUS is used on the second or third overall pass to attempt revascularization.

Exclusion Criteria

• Currently participating in an investigational (drug, device, etc.) clinical trial that may confound study endpoints. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible.
• Confirmation of positive pregnancy test according to site specific standard of care (e.g. test, verbal communication).
• All patients with severe hypertension on presentation (SBP > 220 mmHg and/or DBP > 120 mm Hg). All patients, in whom intravenous therapy with blood pressure medications is indicated, with hypertension that remains severe and sustained despite intravenous antihypertensive therapy (SBP >185 mmHg and/ or DBP >110 mmHg).
• Known cerebral vasculitis.
• Known cancer with life expectancy less than 12 months.
• Stenosis, or any occlusion, in a proximal vessel that requires treatment or prevents access to the site of occlusion.
• Intracranial stenosis that prevents access to the site of occlusion.
• Computed tomography (CT) or Magnetic Resonance Imaging (MRI) evidence of recent/ fresh hemorrhage on presentation.
• Baseline computed tomography (CT) or MRI showing mass effect or intracranial tumor (except small meningioma).
• Evidence of dissection in the extra or intracranial cerebral arteries.
• Occlusions in multiple vascular territories (e.g., bilateral anterior circulation, or anterior/posterior circulation).