N/A
Completed N=120
Comparison of the ToFscan and TetraGraph During Recovery of Neuromuscular Function in the Post Anesthesia Care Unit
Residual Neuromuscular Blockade
Source: ClinicalTrials.gov NCT03920670 ↗
Enrolled (actual)
120
Serious AEs
0.0%
Results posted
Apr 2021
Primary outcomePrimary: Mean Train-of-Four Ratios (TOFR's) — 0.97; 0.94; 0.96; 0.95 Ratio
Summary
The aim of this investigation is to compare the performance of two quantitative monitors utilized on post-anesthesia recovering patients. The ToFscan (Draeger Medical Inc., Telford, PA) represents one of the few standalone acceleromyography (AMG)-based quantitative monitors available for routine clinical use in the United States. The TetraGraph (Senzime AB, Uppsala, Sweden) is a standalone electromyography (EMG)-based quantitative monitor that recently received Conformité Européene (CE) approval. While both of these quantitative monitors can be utilized to guide intraoperative NMBA re-dosing and confirm recovery, they provide their objective data via drastically different techniques.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Train-of-Four Ratios (TOFR's) |
0.97; 0.94; 0.96; 0.95; 0.99; 0.94 | — |
Eligibility Criteria
Inclusion Criteria
- Age > or = 18 years old
- Patients willing to participate and provide an informed consent
- Patients undergoing an elective surgical procedure that requires use of non-depolarizing NMBA agents administered intraoperatively.
Exclusion Criteria
- Patients with unilateral disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
- Patients with systemic neuromuscular diseases such as myasthenia gravis
- Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment or end-stage liver disease.
Data sourced from ClinicalTrials.gov (NCT03920670). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.