N/A N=350 Randomized Double-blind Supportive Care

Modified Application of Cardiac Rehabilitation for Older Adults

Cardiovascular Diseases · Cardiac Rehabilitation · Transition of Care

Bottom Line

View on ClinicalTrials.gov: NCT03922529 ↗

Enrolled (actual)

350

Serious AEs

41.1%

Results posted

Sep 2025

Primary outcome: Primary: AM-PAC-CAT - Basic Mobility Domain — 5.1; 5.0 score on a scale — p=0.5430

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: MACRO-I (Behavioral); Usual Care (Other)
Age: Older Adult · 70+ yrs
Sex: All
Sponsor: Daniel Forman, MD
Primary completion: Aug 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY AM-PAC-CAT - Basic Mobility Domain	4.9; 5.3	0.8842
SECONDARY AM-PAC-CAT - Basic Mobility Domain	4.9; 5.3	0.8842
SECONDARY AM-PAC-CAT - Basic Mobility Domain	4.9; 5.3	0.8842
SECONDARY AM-PAC-CAT - Daily Activity Domain	6.9; 5.1	0.1393
SECONDARY AM-PAC-CAT - Daily Activity Domain	6.9; 5.1	0.1393
SECONDARY AM-PAC-CAT - Daily Activity Domain	6.9; 5.1	0.1393
SECONDARY Accelerometry	44.8; 12.9	0.9920
SECONDARY Accelerometry	44.8; 12.9	0.9920
SECONDARY Accelerometry	44.8; 12.9	0.9920
SECONDARY PATIENT HEALTH QUESTIONNAIRE (PHQ-9)	-1.7; -2.3	0.7966
SECONDARY PATIENT HEALTH QUESTIONNAIRE (PHQ-9)	-1.7; -2.3	0.7966
SECONDARY PATIENT HEALTH QUESTIONNAIRE (PHQ-9)	-1.7; -2.3	0.7966
SECONDARY Morley Frail Scale	-0.6; -0.4	0.1194
SECONDARY Morley Frail Scale	-0.6; -0.4	0.1194
SECONDARY Morley Frail Scale	-0.6; -0.4	0.1194
SECONDARY Sullivan Cardiac Self-Efficacy	2.7; 1.3	0.1932
SECONDARY Sullivan Cardiac Self-Efficacy	2.7; 1.3	0.1932
SECONDARY Sullivan Cardiac Self-Efficacy	2.7; 1.3	0.1932
SECONDARY THE VETERANS RAND 12-ITEM HEALTH SURVEY (RAND-12) - Physical Component Score	7.4; 5.1	0.2574
SECONDARY THE VETERANS RAND 12-ITEM HEALTH SURVEY (RAND-12) - Physical Component Score	7.4; 5.1	0.2574
SECONDARY THE VETERANS RAND 12-ITEM HEALTH SURVEY (RAND-12) - Physical Component Score	7.4; 5.1	0.2574
SECONDARY THE VETERANS RAND 12-ITEM HEALTH SURVEY (RAND-12) - Mental Component Score	4.6; 6.4	0.7327
SECONDARY THE VETERANS RAND 12-ITEM HEALTH SURVEY (RAND-12) - Mental Component Score	4.6; 6.4	0.7327
SECONDARY THE VETERANS RAND 12-ITEM HEALTH SURVEY (RAND-12) - Mental Component Score	4.6; 6.4	0.7327
SECONDARY Cardiac Rehabilitation Participation	10.1; 10.6	0.7651
SECONDARY Hospitalizations	0.69; 0.60	0.3974
SECONDARY Duke Activity Status Index (DASI)	9.1; 8.0	0.4354
SECONDARY Duke Activity Status Index (DASI)	9.1; 8.0	0.4354
SECONDARY Duke Activity Status Index (DASI)	9.1; 8.0	0.4354
SECONDARY Rapid Eating Assessment for Participants (Modified REAP-S)	3.1; 3.0	0.8936
SECONDARY Rapid Eating Assessment for Participants (Modified REAP-S)	3.1; 3.0	0.8936
SECONDARY Rapid Eating Assessment for Participants (Modified REAP-S)	3.1; 3.0	0.8936
SECONDARY Readiness for Change	8; 2; 4; 9; 10; 12	0.1122
SECONDARY Readiness for Change	8; 2; 4; 9; 10; 12	0.1122
SECONDARY Readiness for Change	8; 2; 4; 9; 10; 12	0.1122
SECONDARY Readiness for Change	8; 2; 4; 9; 10; 12	0.1122
SECONDARY Fall Assessment	52; 50	0.9653

Summary

Modified Application of Cardiac Rehabilitation for Older Adults (MACRO) responds to a critical underuse of cardiac rehabilitation in older adults with a coaching model that addresses issues related to aging as a means to better facilitate cardiac rehabilitation (CR). MACRO is a randomized controlled trial (RCT) in which older adults with a CVD event are randomized between a MACRO intervention (MACRO-I) versus usual care. The MACRO-I is designed to facilitate CR as a means to augment functional recovery.

Eligibility Criteria

Inclusion Criteria

Age ≥70 year
Eligible cardiovascular disease (CVD) diagnosis (hospitalization for acute myocardial infarction/ acute coronary syndrome, stable ischemic heart disease, revascularization (coronary artery bypass graft surgery and percutaneous coronary intervention, valvular heart disease (surgical or transcatheter replacements or repair for mitral regurgitation or aortic stenosis),heart failure (exacerbation or new diagnosis)
English speaking
Able to provide written informed consent
Able to be assessed and undergo study interventions

Exclusion Criteria

Unstable medical condition as indicated by history, physical exam, and/or laboratory findings
Presence of non-CVD conditions likely to be fatal within 12 months (e.g., metastatic cancer)
Severe cognitive impairment: Short Blessed screening with a score of 13 or greater cannot consent (as indicated by medical record)
Long-term care resident at admission with no plans to return to independent living
Unable to participate in follow-up assessments by telephone or in person

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03922529). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.