N/A N=1,216 Randomized Single-blind Prevention

Preventing Drug Abuse Among Sexual Minority Youth

Substance Abuse

Bottom Line

View on ClinicalTrials.gov: NCT03954535 ↗

Enrolled (actual)

1,216

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcome: Primary: Average Number of Times Youth Drank Alcohol in the Past Month — 0.83; 1.03 number of times

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Free2b (Behavioral); Attention-Placebo (Behavioral)
Age: Pediatric · 15+ yrs
Sex: All
Sponsor: Columbia University
Primary completion: Mar 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Average Number of Times Youth Drank Alcohol in the Past Month	2.49; 2.67	—
PRIMARY Average Number of Times Youth Drank Alcohol in the Past Month	2.49; 2.67	—
PRIMARY Average Number of Times Youth Drank Alcohol in the Past Month	2.49; 2.67	—
PRIMARY Average Number of Times Youth Drank Alcohol in the Past Month	2.49; 2.67	—
PRIMARY Average Number of Times Youth Binge Drank in the Past Month	0.65; 0.78	—
PRIMARY Average Number of Times Youth Binge Drank in the Past Month	0.65; 0.78	—
PRIMARY Average Number of Times Youth Binge Drank in the Past Month	0.65; 0.78	—
PRIMARY Average Number of Times Youth Binge Drank in the Past Month	0.65; 0.78	—
PRIMARY Average Number of Times Youth Smoked Cigarettes in the Past Month	0.76; 1.05	—
PRIMARY Average Number of Times Youth Smoked Cigarettes in the Past Month	0.76; 1.05	—
PRIMARY Average Number of Times Youth Smoked Cigarettes in the Past Month	0.76; 1.05	—
PRIMARY Average Number of Times Youth Smoked Cigarettes in the Past Month	0.76; 1.05	—
PRIMARY Average Number of Times Youth Smoked Marijuana in the Past Month	8.53; 8.54	—
PRIMARY Average Number of Times Youth Smoked Marijuana in the Past Month	8.53; 8.54	—
PRIMARY Average Number of Times Youth Smoked Marijuana in the Past Month	8.53; 8.54	—
PRIMARY Average Number of Times Youth Smoked Marijuana in the Past Month	8.53; 8.54	—
PRIMARY Average Number of Times Youth Vaped Any Substance in the Past Month	11.99; 11.11	—
PRIMARY Average Number of Times Youth Vaped Any Substance in the Past Month	11.99; 11.11	—
PRIMARY Average Number of Times Youth Vaped Any Substance in the Past Month	11.99; 11.11	—
PRIMARY Average Number of Times Youth Vaped Any Substance in the Past Month	11.99; 11.11	—
PRIMARY Average Number of Times Youth Used Hard Drugs in the Past Month	0.34; 0.62	—
PRIMARY Average Number of Times Youth Used Hard Drugs in the Past Month	0.34; 0.62	—
PRIMARY Average Number of Times Youth Used Hard Drugs in the Past Month	0.34; 0.62	—
PRIMARY Average Number of Times Youth Used Hard Drugs in the Past Month	0.34; 0.62	—
SECONDARY Mean Scores for Goal Setting	2.57; 2.49	—
SECONDARY Mean Scores for Goal Setting	2.57; 2.49	—
SECONDARY Mean Scores for Goal Setting	2.57; 2.49	—
SECONDARY Mean Scores for Goal Setting	2.57; 2.49	—
SECONDARY Mean Scores for Problem Solving	1.99; 2.03	—
SECONDARY Mean Scores for Problem Solving	1.99; 2.03	—
SECONDARY Mean Scores for Problem Solving	1.99; 2.03	—
SECONDARY Mean Scores for Problem Solving	1.99; 2.03	—
SECONDARY Mean Scores for Self-Esteem	2.37; 2.42	—
SECONDARY Mean Scores for Self-Esteem	2.37; 2.42	—
SECONDARY Mean Scores for Self-Esteem	2.37; 2.42	—
SECONDARY Mean Scores for Self-Esteem	2.37; 2.42	—
SECONDARY Mean Scores for Perceived Stress	3.03; 3.14	—
SECONDARY Mean Scores for Perceived Stress	3.03; 3.14	—
SECONDARY Mean Scores for Perceived Stress	3.03; 3.14	—
SECONDARY Mean Scores for Perceived Stress	3.03; 3.14	—
SECONDARY Mean Scores for Coping	2.87; 2.78	—
SECONDARY Mean Scores for Coping	2.87; 2.78	—
SECONDARY Mean Scores for Coping	2.87; 2.78	—
SECONDARY Mean Scores for Coping	2.87; 2.78	—
SECONDARY Mean Scores for Peer Drug Use	0.74; 0.77	—
SECONDARY Mean Scores for Peer Drug Use	0.74; 0.77	—
SECONDARY Mean Scores for Peer Drug Use	0.74; 0.77	—
SECONDARY Mean Scores for Peer Drug Use	0.74; 0.77	—
SECONDARY Mean Scores for Self-Efficacy	2.13; 2.19	—
SECONDARY Mean Scores for Self-Efficacy	2.13; 2.19	—
SECONDARY Mean Scores for Self-Efficacy	2.13; 2.19	—
SECONDARY Mean Scores for Self-Efficacy	2.13; 2.19	—
SECONDARY Mean Scores for Drug Refusal Skills	1.98; 2.05	—
SECONDARY Mean Scores for Drug Refusal Skills	1.98; 2.05	—
SECONDARY Mean Scores for Drug Refusal Skills	1.98; 2.05	—
SECONDARY Mean Scores for Drug Refusal Skills	1.98; 2.05	—
SECONDARY Mean Scores for Assertiveness	2.97; 2.93	—
SECONDARY Mean Scores for Assertiveness	2.97; 2.93	—
SECONDARY Mean Scores for Assertiveness	2.97; 2.93	—
SECONDARY Mean Scores for Assertiveness	2.97; 2.93	—
SECONDARY Mean Scores for Consequences of Substance Use	0.15; 0.13	—
SECONDARY Mean Scores for Consequences of Substance Use	0.15; 0.13	—
SECONDARY Mean Scores for Consequences of Substance Use	0.15; 0.13	—
SECONDARY Mean Scores for Consequences of Substance Use	0.15; 0.13	—

Summary

The planned randomized clinical trial will longitudinally test a tailored, web-based drug abuse prevention program with a nationwide sample of 15- to 17-year-old sexual minority youth (youth who identify as gay, lesbian, bisexual, or unsure of their sexual orientation).

Eligibility Criteria

Inclusion Criteria

teenagers between the ages of 15-17 years old
identify as lesbian, gay, bisexual, or unsure of sexual orientation
speak and read English
access to a private desktop, laptop, or tablet with broadband internet access

Exclusion:

Lives outside the United States of America

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03954535). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.