N/A
N=19
The Adverse Drug Reaction (ADRe) Profile for Polypharmacy
Polypharmacy
Bottom Line
View on ClinicalTrials.gov: NCT03955133 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Aug 2021
Primary outcome: Primary: Number of Participants With Changes in Signs and Symptoms Related to Adverse Effects of Prescribed Medicines. Clinical Gains and Benefits to Residents — 17 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Adverse Drug Reaction ADRe Profile for Polypharmacy (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Swansea University
- Primary completion
- May 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Changes in Signs and Symptoms Related to Adverse Effects of Prescribed Medicines. Clinical Gains and Benefits to Residents |
17 | — |
| SECONDARY Number of Clinical Gains Per Resident Between Baseline and 3 Months |
3 | — |
| SECONDARY Number of Medicines Prescribed: Change Between Baseline and 3 Months |
— | — |
| SECONDARY Number of Problems Listed on Profile |
3 | — |
Summary
Polypharmacy, the use of multiple or inappropriate medications, has the potential to harm older adults by causing cognitive impairment, falls, and hospitalisations. The nurse-led intervention (The ADRe Profile) to review mental health medicines has demonstrated improved care quality by: identifying serious adverse drug reactions (ADRs); reducing prescription of mental health medicines; reducing the prevalence of pain and nausea; and, increasing non-urgent national health service (NHS) contacts. The investigators will develop ADRe to encompass medicines commonly prescribed in primary care and evaluate intervention implementation in care homes in Aneurin Bevan University Health Board.
Eligibility Criteria
Inclusion Criteria
- • Resident at the care home and expected to continue to live there for 1 year
- Currently taking >3 prescribed medicines daily
- Willing and able to give informed, signed consent themselves, or where capacity is lacking, a consultee is willing to give advice and assent to the resident participating.
Exclusion Criteria
- age <18
- Prescribed <4 medicines daily;
- Receiving active palliative care
- Not well enough to participate, as screened by their nurses
Data sourced from ClinicalTrials.gov (NCT03955133). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.