Early Phase 1
Completed N=30
Behavior Brain Responses
Alcohol Drinking · Drinking Behavior · Physiological Effects of Drugs · Central Nervous System Depression
Source: ClinicalTrials.gov NCT03964350 ↗
Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcomePrimary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions — 3.65; 45.5; 62.3; 3.0 units on a scale — p=<.05
Summary
To compare responses to acute oral doses of ethanol in healthy young adults who experience mainly stimulant subjective effects from the drug or mainly sedative effects.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions |
3.65; 45.5; 62.3; 3.0; 33.7; 47.0 | <.05 sig |
Eligibility Criteria
- 21-35 years old
- 4-30 alcoholic drinks per week (as reported on PHQ or TLFB)
- No 'flushing' reaction to alcohol
- BMI 19-26
- High school education or greater, fluent in English
- No night shift work
- No current or past year Axis I psychiatric disorder including drug/alcohol dependence
- No current psychopharmacological treatment
- No lifetime ADHD or prescription for ADHD medication
- No abnormal EKG, cardiovascular illness, high blood pressure
- No medical condition or pharmacological treatment for which alcohol is contraindicated
- Not pregnant, lactating, or planning to become pregnant
- Smoke <6 cigarettes per day
Data sourced from ClinicalTrials.gov (NCT03964350). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.