N/A
N=9,501
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
Cardiovascular Diseases · Adherence, Medication · Medication Adherence · Diabetes Mellitus · Hypertension
Bottom Line
View on ClinicalTrials.gov: NCT03973931 ↗Enrolled (actual)
9,501
Serious AEs
12.3%
Results posted
Apr 2025
Primary outcome: Primary: Medication Adherence — .606; .620; .623; .630 mean PDC — p=<0.05
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Nudge (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Colorado, Denver
- Primary completion
- May 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Medication Adherence |
.606; .620; .623; .630 | <0.05 sig |
| PRIMARY Mean Proportion of Days Covered Relative to Usual Care |
0.022; 0.020; 0.023 | <0.05 sig |
| SECONDARY Hospitalization |
.13; .136; .136; .143 | — |
| SECONDARY Death |
.031; .026; .027; .033 | — |
| SECONDARY Emergency Department Visit |
.292; .285; .294; .301 | — |
Summary
The study plans to learn if sending different text messages, serving as reminders or encouragement, may help patients take their medication more often if they have had trouble keeping up with their medicines.
Eligibility Criteria
Inclusion Criteria
- Patients with the following cardiovascular conditions and respective medication classes:
- Hypertension (Beta-blockers [B-blockers)], Calcium Channel Blocker [CCB], Angiotensin converting enzyme inhibitors (ACEi), Angiotensin Receptor Blockers [ARB], or Thiazide diuretic)
- Hyperlipidemia (HMG CoA reductase inhibitor [Statins])
- Diabetes (Alpha-glucosidase inhibitors, Biguanides, DPP-4 inhibitors, Sodium glucose transport inhibitor, Meglitinides, Sulfonylureas, Thiazolidinediones, or statins Coronary artery disease P2Y12 inhibitor [Clopidogrel, Ticagrelor, Prasugrel, Ticlopidine], B-blockers, ACEi or ARB or statins)
- Atrial fibrillation (Direct oral anticoagulants, B-blockers, CCB)
Exclusion Criteria
- Patients who do not have a mailing address listed in EHR;
- Patients who do not have a landline or cellphone listed in EHR;
- Currently pregnant if denoted in the EHR at the time of the data pull;
- Patients with a mailing address outside of the state of Colorado;
- Patients that do not speak either English or Spanish.
Data sourced from ClinicalTrials.gov (NCT03973931). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.