Phase 4 Completed N=61 Randomized Single-blind Treatment

Pain Control in Colorectal Surgery: Liposomal Bupivacaine Block Versus Intravenous Lidociane

Colorectal Disorders

Source: ClinicalTrials.gov NCT04005859 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2021

Primary outcomePrimary: Verbal Pain Scale (VRS) - 4 Week Post-op — 0.4; 1.1 score on a scale

◆ Published Evidence

No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

To compare the analgesic impact of intravenous perioperative lidocaine infusion with preoperative liposomal bupivacaine TAP block in colorectal surgery. This is to be integrated into the standard ERAS protocol currently utilized at Carolinas Medical Center. Primary endpoints will be postoperative pain as measured by verbal rate scale (VRS), postoperative morphine equivalents utilized per day, and over 30 days. Secondary endpoints will include date of ambulation, return of bowel function (first flatus), tolerance of goal diet, incidence of post-operative nausea and vomiting during hospital stay, length of stay (hospital and PACU), post-operative morbidity (Clavien-Dindo, related to both anesthesia and surgery), cost of hospitalization (operative, PACU, postoperative stay, and total) and quality of life on follow up.

Outcome Measures

Outcome	Result	p-value
PRIMARY Verbal Pain Scale (VRS) - 4 Week Post-op	0.4; 1.1	—

Eligibility Criteria

Inclusion Criteria

Age 18-75 years
Elective laparoscopic colorectal surgery
ASA I-III

Exclusion Criteria

Contraindication to Na Channel Blocker
Chronic Opioid use
Liver dysfunction
Renal insufficiency
Epilepsy
Psychomotor retardation
BMI >40
Sleep Apnea
Cardiac Rhythm Disorders
Planned open or concomitant procedure

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04005859). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.