N/A
N=61
Dementia Risk and Dynamic Response to Exercise
Alzheimer Disease 2 Due to Apoe4 Isoform · Healthy Aging
Bottom Line
View on ClinicalTrials.gov: NCT04009629 ↗Enrolled (actual)
61
Serious AEs
0.0%
Results posted
May 2022
Primary outcome: Primary: Cerebral Blood Flow Area Under Curve — 715; 751 mL/100g tissue
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Moderate Intensity Aerobic Exercise (Behavioral)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- University of Kansas Medical Center
- Primary completion
- Oct 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cerebral Blood Flow Area Under Curve |
715; 751 | — |
| SECONDARY Insulin-like Growth Factor-1 Change |
2.25; 5.7 | — |
| SECONDARY Vascular Endothelial Growth Factor Change |
-1.01; 1.83 | — |
| SECONDARY Brain Derived Neurotrophic Factor Change |
-219; 208 | — |
Summary
Research suggests that physical exercise supports brain health and cognition as we age. The goal of this project is to examine the specific changes in brain blood flow and biological factors in the blood immediately after exercise in older adults who have the APOE4 gene, a genetic risk factor for developing Alzheimer's. Results from this study will help researchers and clinicians understand and measure changes in the body and brain as a function of exercise, and how those changes relate to Alzheimer's risk.
Eligibility Criteria
Inclusion Criteria
- Age 65-85
- English speaking
- Normal or corrected hearing or vision,
- Without activity restrictions.
Exclusion Criteria
- Clinically significant cognitive or psychiatric illness,
- Anti- coagulant use,
- High cardiovascular risk without physician clearance for exercise,
- Exercise-limiting musculoskeletal condition,
- MRI contraindications
Data sourced from ClinicalTrials.gov (NCT04009629). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.