N/A
Completed N=48
Acute Effects of Alcohol Use on Chronic Orofacial Pain
Temporomandibular Joint Disorders
Source: ClinicalTrials.gov NCT04019093 ↗
Enrolled (actual)
48
Serious AEs
0.0%
Results posted
Jul 2023
Primary outcomePrimary: Pressure Pain Threshold — 4.56; 5.27; 3.81; 4.51 lbf — p=.99
Summary
Self-medication of pain with alcohol is a common, yet risky, behavior among individuals with chronic orofacial pain. Chronic pain status may affect the degree to which alcohol use relieves pain, but the independent contributions of pain chronification and alcohol-related expectations and conditioning have not been previously studied. This project addresses this gap in knowledge and will inform further research and clinical/translational efforts for reducing risk associated with these behaviors.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pressure Pain Threshold |
4.56; 5.27; 3.81; 4.51 | .99 |
| PRIMARY Pressure Pain Intensity |
23.96; 12.76; 32.39; 22.05; 35.43; 20.92 | .76 |
| PRIMARY Perceived Relief |
40.58; 39.79; 7.91; 5.51; 41.00; 42.75 | .50 |
Eligibility Criteria
Inclusion Criteria
- Positive diagnosis of jaw pain, including temporomandibular joint and muscle disorder (TMD) (jaw pain group only)
- Consume at least 1 drink/month over the past 6 months
Exclusion Criteria
- History of chronic pain other than jaw pain or TMD
- Current use of opioids
- Current major depression
- History of any psychotic disorder
- Undercontrolled hypertension or diabetes
- History of neurologic disease
- History of serious medical illness
- History of drug or alcohol dependence, including nicotine, or a pattern of hazardous alcohol use
Data sourced from ClinicalTrials.gov (NCT04019093). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.