N/A N=48 Randomized Double-blind Basic Science

Acute Effects of Alcohol Use on Chronic Orofacial Pain

Temporomandibular Joint Disorders

Bottom Line

View on ClinicalTrials.gov: NCT04019093 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2023

Primary outcome: Primary: Pressure Pain Threshold — 4.56; 5.27; 3.81; 4.51 lbf — p=.99

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Ethanol (Drug); Placebo (Other)
Age: Adult · 21+ yrs
Sex: All
Sponsor: University of Florida
Primary completion: Apr 2022

Outcome Measures

Outcome	Result	p-value
PRIMARY Pressure Pain Threshold	4.56; 5.27; 3.81; 4.51	.99
PRIMARY Pressure Pain Intensity	23.96; 12.76; 32.39; 22.05; 35.43; 20.92	.76
PRIMARY Perceived Relief	40.58; 39.79; 7.91; 5.51; 41.00; 42.75	.50

Summary

Self-medication of pain with alcohol is a common, yet risky, behavior among individuals with chronic orofacial pain. Chronic pain status may affect the degree to which alcohol use relieves pain, but the independent contributions of pain chronification and alcohol-related expectations and conditioning have not been previously studied. This project addresses this gap in knowledge and will inform further research and clinical/translational efforts for reducing risk associated with these behaviors.

Eligibility Criteria

Inclusion Criteria

Positive diagnosis of jaw pain, including temporomandibular joint and muscle disorder (TMD) (jaw pain group only)
Consume at least 1 drink/month over the past 6 months

Exclusion Criteria

History of chronic pain other than jaw pain or TMD
Current use of opioids
Current major depression
History of any psychotic disorder
Undercontrolled hypertension or diabetes
History of neurologic disease
History of serious medical illness
History of drug or alcohol dependence, including nicotine, or a pattern of hazardous alcohol use

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04019093). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.