N/A
N=23
Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
Periodontitis Chronic Generalized Moderate · Periodontitis Chronic Generalized Severe
Bottom Line
View on ClinicalTrials.gov: NCT04027686 ↗Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Mar 2021
Primary outcome: Primary: Probing Pocket Depth — 4.167; 4.273 mm
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Laser Therapy (Device); Non-surgical Scaling and Root Planing (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of California, Los Angeles
- Primary completion
- Dec 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Probing Pocket Depth |
4.167; 4.273 | — |
| PRIMARY Sites That Bleed on Probing |
55.1; 63.6 | — |
| PRIMARY Gingival Recession |
1.167; 1.182 | — |
| PRIMARY Clinical Attachment Level |
5.346; 5.455 | — |
| SECONDARY Periodontal Microbiome |
— | — |
| SECONDARY Patient Reported Outcomes: VAS Questionnaire |
2.316; 1.056; 100; 100; 16.158; 20.833 | — |
Summary
The use of lasers to treat various problems in dentistry is growing as it has in medicine. One application is the use of lasers to treat periodontal disease. It has been suggested that the laser may reduce the need for surgical treatment by reducing pockets. The goal of this study is to evaluate the effectiveness of laser treatment for periodontal disease. Laser therapy will be used in addition to traditional non-surgical scaling and root planing (deep cleaning). The information obtained from this study will provide an objective assessment of adjunctive laser therapy compared to conventional periodontal therapy and will attempt to show the benefits, if any, lasers can provide in the treatment of chronic periodontal disease.
Eligibility Criteria
Inclusion Criteria
- Age 18 years old or older (male or female)
- Healthy without systemic diseases that may adversely effect healing
- Not pregnant and no current plans to become pregnant
- No periodontal treatment in the previous 12 months
- No systemic antibiotic therapy in the previous 6 months
- At least two quadrants with periodontitis (ideally opposite side same jaw)
- Each quadrant must have two or more sites with probing pocket depths ≥ 5mm
- Each quadrant should include interproximal intrabony defect(s)
Exclusion criteria
- Any systemic disease, medication, or habit known to adversely influence bone metabolism and/or wound healing:
- Poorly controlled diabetes (HbA1c > 7%)
- History of bisphosphonate medications
- History of radiation therapy affecting the proposed treatment site(s)
- History of immunosuppressive medications (e.g. corticosteroids)
- History of tobacco use (current or past tobacco use within the past 1 year)
- Immune compromise caused by disease, treatment or other condition
- Recent history of periodontal surgery (within the previous 2 years)
- Recent history of scaling and root planing (within the previous 12 months)
- Any condition that contraindicates periodontal therapy including surgery
Data sourced from ClinicalTrials.gov (NCT04027686). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.