N/A
N=36
Mercury Metabolism by Bacteria in Humans
Mercury--Toxicology
Bottom Line
View on ClinicalTrials.gov: NCT04060212 ↗Enrolled (actual)
36
Serious AEs
0.0%
Results posted
Nov 2022
Primary outcome: Primary: Mercury Elimination Rate Before Pre-biotic — 48.5 days
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Tuna fish (Other); prebiotic (Dietary_supplement)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Rochester
- Primary completion
- May 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mercury Elimination Rate Before Pre-biotic |
48.5 | — |
| PRIMARY Mercury Elimination Rate After Pre-biotic |
49.1 | — |
| SECONDARY Change in Mercury Metabolism Ratio |
— | — |
Summary
The purpose of this study is to evaluate how the bacteria in your gut can improve the break-down and de-toxification of non-harmful levels of a naturally occurring form of mercury (methylmercury) that comes with eating fish. This research could help scientists and doctors understand whether or not mercury in fish that we are likely to eat poses any concern for the health of people.
Eligibility Criteria
Inclusion Criteria
- Subjects must be 18-80 years in age.
- Subjects must be in good general health based on self-reported health status, with the exception of self-reported conditions listed in the exclusion criteria.
- Subject must be willing to comply with study procedures.
Exclusion Criteria
- Known allergy to fish.
- Pregnant or lactating women.
- Use of hair dyes or chemical treatments within the prior month and/or intent to use such treatments during the two trial periods. (Hair treatment during the washout period up to one month prior to the second trial is acceptable).
- Known gastrointestinal or renal disorders.
- Subjects with diminished mental capacity.
- Use of antibiotics within two months leading up to the study.
Data sourced from ClinicalTrials.gov (NCT04060212). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.