Phase 4
Completed N=20
Effect of Epinephrine on Post-polypectomy Pain
Colonic Polyp
Source: ClinicalTrials.gov NCT04065451 ↗
Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Sep 2022
Primary outcomePrimary: Immediate Post-polypectomy Pain — 46.5; 13.6 units on a scale
◆ Published Evidence
Emerging
16citations · ~4 / year
Impact of including epinephrine in the submucosal injectate for colorectal EMR on postprocedural pain: a randomized controlled trial.
Summary
Epinephrine is widely used in endoscopic mucosal resection of large polyps to prevent post-polypectomy bleeding. No previous studies looked at increase in immediate post-polypectomy pain with the use of epinephrine.
Linked Publications
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Impact of including epinephrine in the submucosal injectate for colorectal EMR on postprocedural pain: a randomized controlled trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Immediate Post-polypectomy Pain |
46.5; 13.6 | — |
| PRIMARY Immediate Post Polypectomy Pain (1hour) |
44; 12.9 | — |
| SECONDARY en Bloc Resection |
0; 0; 11; 10 | — |
| SECONDARY Sydney Resection Quotient |
5; 4.2 | — |
| SECONDARY Quality of the Mound |
9; 8; 0; 2; 2; 0 | — |
| SECONDARY Frequency of Immediate Bleeding |
2; 4; 9; 6 | — |
Eligibility Criteria
Inclusion Criteria
- Patients aged 18 years and over
- Patients scheduled for treatment of large (≥ 20 mm) colorectal polyps
- Able to sign informed consent
Exclusion Criteria
- Patients previously enrolled in the study
- Pedunculated polyps
- Polyps not amenable to endoscopic resection
- Patients allergic or sensitive to epinephrine
- Patients with coronary artery disease who have had a myocardial infarction in the past year, or had coronary stenting in the past year, or had angina in the past year.
- Patients electing anesthesia other than monitored anesthesia care with propofol (MAC) for colonoscopy
Data sourced from ClinicalTrials.gov (NCT04065451) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.