Phase 4
N=20
Effect of Epinephrine on Post-polypectomy Pain
Colonic Polyp
Bottom Line
View on ClinicalTrials.gov: NCT04065451 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Sep 2022
Primary outcome: Primary: Immediate Post-polypectomy Pain — 46.5; 13.6 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Epinephrine (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Indiana University
- Primary completion
- Aug 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Immediate Post-polypectomy Pain |
46.5; 13.6 | — |
| PRIMARY Immediate Post Polypectomy Pain (1hour) |
44; 12.9 | — |
| SECONDARY en Bloc Resection |
0; 0; 11; 10 | — |
| SECONDARY Sydney Resection Quotient |
5; 4.2 | — |
| SECONDARY Quality of the Mound |
9; 8; 0; 2; 2; 0 | — |
| SECONDARY Frequency of Immediate Bleeding |
2; 4; 9; 6 | — |
Summary
Epinephrine is widely used in endoscopic mucosal resection of large polyps to prevent post-polypectomy bleeding. No previous studies looked at increase in immediate post-polypectomy pain with the use of epinephrine.
Eligibility Criteria
Inclusion Criteria
- Patients aged 18 years and over
- Patients scheduled for treatment of large (≥ 20 mm) colorectal polyps
- Able to sign informed consent
Exclusion Criteria
- Patients previously enrolled in the study
- Pedunculated polyps
- Polyps not amenable to endoscopic resection
- Patients allergic or sensitive to epinephrine
- Patients with coronary artery disease who have had a myocardial infarction in the past year, or had coronary stenting in the past year, or had angina in the past year.
- Patients electing anesthesia other than monitored anesthesia care with propofol (MAC) for colonoscopy
Data sourced from ClinicalTrials.gov (NCT04065451). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.