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N/A N=382 Randomized Triple-blind Prevention

Chronic HBV Management for Asian American

Hepatitis B, Chronic

Enrolled (actual)
382
Serious AEs
0.0%
Results posted
Jun 2023
Primary outcome: Primary: Adherence to Recommended HBV Monitoring: Doctor's Visits — 159; 100; 170; 147 Participants

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
VPN (Behavioral); TM (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Temple University
Primary completion
Mar 2022

Outcome Measures

OutcomeResultp-value
PRIMARY
Adherence to Recommended HBV Monitoring: Doctor's Visits
159; 100; 170; 147

Summary

About 75% of liver cancers are attributed to chronic hepatitis B (CHB). An estimated 2.2 million individuals in the U.S. have CHB. Although Asian Americans make up 6% of total U.S. population, they account for over 58% of Americans with CHB. Prevalence rates of CHB range from 8% to 13% in Asian Americans vs 1% in Non-Hispanic whites (NHW). Asian Americans are 8-13 times more likely to develop liver cancer with 60% higher death rate than NHW. Regular monitoring of CHB is vital in preventing HCC. Research indicates that regular monitoring (e.g., every six months doctor visit; blood tests) combined with antiviral treatment when appropriate, is critical to reduce the risk of liver disease (including HCC). Unfortunately, treatment effectiveness diminishes if CHB patients do not adhere to long-term monitoring and treatment guidelines. Adherence among Asian Americans with CHB is low. Poor healthcare access and significant cultural barriers prevent long-term adherence to monitoring and optimal treatment, placing Asian Americans at disproportionately high risk for HCC and increased healthcare costs. Building on previous studies, the investigators will use a virtual patient navigation (VPN) toolkit system (a web/mobile application) to help CHB patients improving their liver disease management.

Eligibility Criteria

Inclusion Criteria

  • 1. Age 18 and above
  • 2. Self-identified Chinese, Korean or Vietnamese ethnicity
  • 3. Chronic HBV infection with positive HBV surface antigen (HBsAg)
  • 4. Non-compliant to HBV monitoring and treatment guidelines

Exclusion Criteria

-

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04082338). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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