N/A
N=31
Thumb Osteoarthritis: A Cross-Sectional Study of Mechanisms
Carpometacarpal Osteoarthritis
Bottom Line
View on ClinicalTrials.gov: NCT04104477 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcome: Primary: Australian Canadian OA Hand Index (AUSCAN) — 3.3; 1.3; 2.0; 1.6 score on a scale
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Range of Motion Tasks (Other); Strength Tasks (Other)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- Female
- Sponsor
- University of Florida
- Primary completion
- Dec 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Australian Canadian OA Hand Index (AUSCAN) |
3.3; 1.3; 2.0; 1.6; 3.7; 1.6 | — |
| PRIMARY Disabilities of the Arm, Shoulder, and Hand (DASH) |
27.8; 15.3 | — |
Summary
This study examines carpometacarpal osteoarthritis (CMC OA) and aims to elucidate the biomechanical, neuromuscular, and somatosensory mechanisms that contribute to CMC OA symptoms by using orthopaedic biomechanics and quantitative pain testing. Completion of this study will provide a comprehensive dataset describing how movement strategies (muscle activity and joint posture) as well as experimental and clinical pain differ between individuals with CMC OA and age-matched controls.
Eligibility Criteria
Inclusion Criteria
- CMC OA Subjects:
- female between the age of 40 to 90 years
- end-stage CMC OA diagnosed by a board-certified clinician
- Age-Matched Control:
- female between the age of 40 to 90 years
- no joint or muscle pain in the hand or wrist
Exclusion Criteria
- All Groups:
- pregnant women; minors (under age 18); mentally disabled; any persons incarcerated, on parole, on probation, or awaiting trial
- individuals with concomitant musculoskeletal pathologies (other than osteoarthritis) in the hand or wrist, including distal radius fracture, contracture, trigger finger, and carpal tunnel
- individuals with history of uncontrolled diabetes, rheumatoid arthritis, muscular dysfunction, or neurological disease
Data sourced from ClinicalTrials.gov (NCT04104477). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.