Phase 4
Completed N=22
Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)
Chronic Pain Due to Injury
Source: ClinicalTrials.gov NCT04105998 ↗
Enrolled (actual)
22
Serious AEs
0.0%
Results posted
Nov 2022
Primary outcomePrimary: Fluctuation in Pupil Diameter (Hippus) -Pre Drug Administration — 1.61; 1.71 milliseconds^2 — p=0.64
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The goal of this study is to test the effects of oxytocin on heart rate variability and pupil diameter, both of which have subtle effects on the activity rate of the autonomic nervous system.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Fluctuation in Pupil Diameter (Hippus) -Pre Drug Administration |
1.61; 1.71 | 0.64 |
| PRIMARY Fluctuation in Pupil Diameter (Hippus) -Post Drug Administration |
0.98; 1.49 | 0.067 |
| PRIMARY Heart Rate Variability in the High Frequency Range |
247; 381 | 0.111 |
Eligibility Criteria
Inclusion Criteria
- Male or female > 18 and < 66 years of age,
- Body Mass Index (BMI) <40
- Generally in good health as determined by the Principal Investigator based on prior medical history
- Normal blood pressure and resting heart rate without medication
Exclusion Criteria
- Hypersensitivity, allergy, or significant reaction to any ingredient of Pitocin®
- Any disease, diagnosis, or condition (medical or surgical) that, in the opinion of the Principal Investigator, would place the subject at increased risk
- Women who are pregnant (positive result for serum pregnancy test at screening visit),
- Women who are currently nursing or lactating, women that have been pregnant within 2 years.
- Neuropathy, chronic pain, diabetes mellitus, or taking benzodiazepines or pain medications on a daily basis.
- Previous eye surgery, eye medications, cataracts
Data sourced from ClinicalTrials.gov (NCT04105998). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.