N/A
Completed N=38
rTMS to Enhance Cognitive Performance and Promote Resilience
Cognition · Stress Reaction
Source: ClinicalTrials.gov NCT04123496 ↗
Enrolled (actual)
38
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcomePrimary: Mean Score of Neurocognitive Performance (Fluid Cognition) — 63.500; 50.250; 59.750; 57.250 score on a scale
Summary
The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as well as to improve the ability to recover from stressful situations (stress resilience).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Score of Neurocognitive Performance (Fluid Cognition) |
63.500; 50.250; 59.750; 57.250; 60.500; 65.250 | — |
| PRIMARY Change From Baseline in Neurocognitive Performance at 1 Week Post Treatment (Fluid Cognition) |
72.500; 63.750; 67.750; 69.500; 70.000; 73.250 | — |
| PRIMARY Change From Baseline in Neurocognitive Performance at 1 Month Post Treatment (Fluid Cognition) |
73.333; 65.000; 68.000; 71.250; 71.750; 68.333 | — |
| SECONDARY Mean Score of Stress Resilience as Assessed by Connor Davidson Resilience Scale |
69.000; 68.000; 80.000; 82.000; 84.500; 73.000 | — |
| SECONDARY Mean Score of Stress Resilience as Assessed by Perceived Stress Scale-10 |
13.000; 12.750; 8.250; 6.750; 5.250; 10.500 | — |
| SECONDARY Mean Score of Stress Resilience as Assessed by Inventory of Depression and Anxiety Symptoms-II |
140.250; 138.500; 142.750; 127.000; 122.500; 150.750 | — |
| SECONDARY Mean Score of Neurocognitive Performance (WINSCAT Composite) |
401.667; 380.333; 405.750; 414.750; 448.250; 424.500 | — |
| SECONDARY Mean Score of Neurocognitive Performance (Stress Total Score) |
13.333; 11.000; 11.000; 6.750; 5.250; 7.750 | — |
Eligibility Criteria
Inclusion Criteria
- No history of mental or physical illness
- No implanted metal in the body
- College graduates (Associates degree or higher)
- Negative urine pregnancy test, if female subject of childbearing potential
- Able to read and understand questionnaires and informed consent
Exclusion Criteria
- Any current psychiatric diagnosis or current Clinical Global Impression ratings of psychiatric illness > 1
- Current physical illness
- History of CNS disease, concussion, overnight hospitalization, tumors, seizures, meningitis, encephalitis, abnormal CT/MRI of the brain
- Moderate to severe traumatic brain injury (TBI)
- History of a continuing significant laboratory finding
- Frequent or severe headaches
- Any history of psychotropic medication prior to study enrollment
- Females of childbearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control.
- active participation or plan for enrollment in another evidence-based clinical trial affecting psychosocial function
- repeated abuse or dependence upon drugs (excluding nicotine and caffeine)
- implanted devices/ferrous metal of any kind
Data sourced from ClinicalTrials.gov (NCT04123496). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.