N/A
N=40
Measurement of Agricultural and Dietary Glyphosate Exposure Among Pregnant Women
Exposure to Herbicides
Bottom Line
View on ClinicalTrials.gov: NCT04155463 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Apr 2023
Primary outcome: Primary: Specific Gravity-adjusted Urinary Glyphosate Concentrations During Conventional and Organic Diet — 0.19; 0.17; 0.18; 0.14 ug/L — p=0.17
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Organic Diet (Other); Conventional Diet (Other)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Boise State University
- Primary completion
- Jun 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Specific Gravity-adjusted Urinary Glyphosate Concentrations During Conventional and Organic Diet |
0.19; 0.17; 0.18; 0.14; 0.21; 0.20 | 0.17 |
Summary
The purpose of this research is to understand whether and how pregnant women may be exposed to glyphosate, the active ingredient in a common herbicide. The researchers aim to assess glyphosate exposure among pregnant women in Idaho, and to attribute that exposure to agricultural and dietary sources. Pregnant women who live either near or far from glyphosate-treated fields will be recruited for study inclusion, and exposure will be assessed via urinary biomonitoring on a weekly basis throughout pregnancy. Each participant will also take part in a two-week dietary intervention, during which they will receive one week of organic food and one week of conventional food, in a crossover design. Urinary biomonitoring will occur on a daily basis during the dietary intervention phase. The researchers hypothesize that women who live near agricultural fields treated with glyphosate will have higher exposures than those who live in non-agricultural regions, and that consumption of an organic diet will reduce exposures in both groups. All study components will be completed with no face-to-face interaction to eliminate all coronavirus (COVID-19) related risks.
Eligibility Criteria
Inclusion Criteria
- Be in the first trimester of pregnancy
- No diagnosis of gestational diabetes or other high risk pregnancy factors
- Consume an exclusively conventional diet with no intentions to switch to an organic diet
- Agree to refrain from applying residential glyphosate (Round Up) during the study
- Either live more than 10 miles or less than 1 mile from a glyphosate treated field
Exclusion Criteria
- Occupational exposure to glyphosate, or live in a household with an individual with occupational glyphosate exposure
Data sourced from ClinicalTrials.gov (NCT04155463). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.