N/A
Completed N=112
Million Veteran Program Return of Actionable Results
Source: ClinicalTrials.gov NCT04178122 ↗Enrolled (actual)
112
Serious AEs
—
Results posted
Oct 2025
Primary outcomePrimary: LDL-C Change — -8.0; 2.4 mg/dL
Summary
The purpose of the Million Veteran Program- Return of Actionable Results (MVP-ROAR) Study is to develop a process to return medically actionable genetic results to living MVP participants nationwide and to determine the impact of doing so on medical management and outcomes and Veteran quality of life.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY LDL-C Change |
-8.0; 2.4 | — |
| SECONDARY LDL-C Target |
15; 14 | — |
| SECONDARY Pharmacotherapy |
11; 5 | — |
Eligibility Criteria
Inclusion Criteria
- Living enrollee in MVP
- Is identified to have a pathogenic or likely pathogenic variant in the gene(s) of interest in MVP genotype data
Exclusion Criteria
- Previously underwent genetic testing for the condition of interest
- Is incarcerated
- Is pregnant
Data sourced from ClinicalTrials.gov (NCT04178122). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.