Phase 4
N=7
Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans
Human Microbiome
Bottom Line
View on ClinicalTrials.gov: NCT04218799 ↗Enrolled (actual)
7
Serious AEs
0.0%
Results posted
Apr 2020
Primary outcome: Primary: Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization — -4174 fg/uL
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Intranasal Mupirocin and Topical Chlorhexidine (Drug)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- University of Maryland, Baltimore
- Primary completion
- Sep 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization |
-4174 | — |
| PRIMARY Change in the Abundance of Staphylococcus Aureus in the Throat After Decolonization |
-3395 | — |
| PRIMARY Change in the Abundance of Gram Negative Bacteria on the Subclavian Skin After Decolonization |
— | — |
| PRIMARY Change in the Abundance of Gram Negative Bacteria on the Femoral Skin After Decolonization |
— | — |
Summary
The purpose of the research is to find out the effect of commonly used topical antibiotics on the bacteria that live in the nose, throat and on the skin of older adults. In addition, the investigators want to determine if these topical antibiotics affect how bacteria are spread in Community Living Centers of the VA Maryland Health Care System.
Eligibility Criteria
Inclusion Criteria
- Age 50 years or older.
- Living in a participating nursing home for at least 80% of the past 3 months-
- Willing to provide anterior nares, posterior pharynx, skin and throat specimens over the study period.
- Willing to use intranasal mupirocin and topical chlorhexidine over a five day period.
- Provide signed and dated informed consent from subject or LAR.
Exclusion Criteria
- Recent history of MRSA colonization
- Use of mupirocin nasal ointment in past 3 months
- Use of topical chlorhexidine in past 3 months
- History of an allergic reaction to chlorhexidine or mupirocin
Data sourced from ClinicalTrials.gov (NCT04218799). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.