N/A Completed N=14 Randomized Double-blind Treatment

Pancreatic Endotherapy for Refractory Chronic Pancreatitis

Pancreatic Duct Stone · Pancreatic Duct Stricture · Pancreatic Duct Dilatation

Source: ClinicalTrials.gov NCT04232670 ↗

Enrolled (actual)

Serious AEs

71.4%

Results posted

Sep 2025

Primary outcomePrimary: Percent Change in Average Daily Pain Score on the Numeric Rating Scale — -36.6; -53.7 Percent Change

Summary

The purpose of this study is to evaluate whether endoscopic ultrasound (EUS) only versus EUS + endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic endotherapy reduces pain in the treatment of chronic pancreatitis with pancreatic duct obstruction.

Outcome Measures

Outcome	Result	p-value
PRIMARY Percent Change in Average Daily Pain Score on the Numeric Rating Scale	-36.6; -53.7	—

Eligibility Criteria

Inclusion Criteria

Age ≥ 18 years
Main pancreatic duct obstruction, defined by the presence of one or both of the following features:
Main pancreatic duct calcification with upstream main duct dilation ≥6mm.
Main pancreatic duct stricture, defined by the presence of main pancreatic duct narrowing with upstream main duct dilation ≥6mm.
Baseline average abdominal pain score ≥4 during the run-in period, based on Ecological Momentary Assessment 11-point Numeric Rating Scale
Ability to provide written, informed consent

Exclusion Criteria

Symptoms attributable to a pancreatic pseudocyst or walled off necrosis
Clinical suspicion of pancreatobiliary malignancy*
Low probability of follow-up to complete study objectives
Pregnancy or incarceration
Medical comorbidities that contraindicate the performance of ERCP
Previous pancreatic endotherapy
Current Opioid Misuse Measure score ≥9
Does not have access to a mobile phone * Pancreatobiliary malignancy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04232670). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.