N/A
N=16
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome
Skeletal Muscle Protein Synthesis
Bottom Line
View on ClinicalTrials.gov: NCT04263714 ↗Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Nov 2024
Primary outcome: Primary: Change in Acute Muscle Protein Synthesis — 143; 123 percent change
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Exercise (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- McMaster University
- Primary completion
- Jul 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Acute Muscle Protein Synthesis |
143; 123 | — |
Summary
Generally, resistance exercise increases muscle mass and strength, and fatigue resistance. How resistance exercise achieves these adaptations remains understudied, but what is known is that skeletal muscle translates the physical and biochemical stresses of resistance exercise into morphological and metabolic adaptations. While resistance exercise activates signaling pathways (i.e., proteins) that increase the synthesis of specific proteins to cause adaptations, thousands of proteins are likely involved, and their interactions are complicated. The investigators aim to study these processes.
Eligibility Criteria
Inclusion Criteria
- between the ages of 18 and 30 years
Exclusion Criteria
- Smoker or user of tobacco products;
- High physical activity
- Have health problems such as: renal or gastrointestinal disorders, metabolic disease, heart disease, vascular disease, rheumatoid arthritis, diabetes, poor lung function, uncontrolled blood pressure, dizziness, thyroid problems, or any other health conditions for which you are being treated that might put you at risk for this study;
- Taking anti-diabetic, anti-inflammatory, platelet inhibitor, or anti-coagulant medications;
- Use of an investigational drug product within the last 30 days;
- Have participated in an infusion protocol in the last year; or
- Do not understand English or have a condition the PI believes would interfere with a participants' ability to provide informed consent, comply with the study protocol, or which might confound the interpretation of the study results or put someone at undue risk.
Data sourced from ClinicalTrials.gov (NCT04263714). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.