Phase 2
N=77
Intralesional Vitamin D Injection for Treatment of Common Warts
Warts
Bottom Line
View on ClinicalTrials.gov: NCT04278573 ↗Enrolled (actual)
77
Serious AEs
0.0%
Results posted
Apr 2024
Primary outcome: Primary: Complete Regression of Wart — 12; 10 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Vitamin D3 (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Stephen P. Merry
- Primary completion
- Apr 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Complete Regression of Wart |
12; 10 | — |
| SECONDARY Regression of Wart at 4 Weeks |
2; 2 | — |
| SECONDARY Regression of Wart at 8 Weeks |
4; 7 | — |
| SECONDARY Regression of Wart at 12 Weeks |
7; 8 | — |
Summary
Researchers are trying to find out if injecting Vitamin D into a wart is an effective treatment.
Eligibility Criteria
Inclusion Criteria
- Adult patients seen at the Mayo Clinic Rochester practices
- Patients suffering from one or more cutaneous warts as diagnosed by the examining physician at baseline visit on typical diagnostic characteristics
- Able to provide consent
- Both recalcitrant and non-recalcitrant warts will be included
Exclusion Criteria
- Patients with prior use of home or office-based destructive treatments for this wart(s) in the last 1 month with salicylic acid (SA) or cryotherapy
- Immunoadjuvant therapy for warts in the last 4 months (e.g Candida)
- History of vitamin D injection of warts ever
- High-dose vitamin D supplementation (>4, 000 IU daily or equivalent) in the preceding 3 months
- Pregnancy or lactation
- Facial or genital warts
- Lesions not felt by the examining clinician to be a wart (e.g., corns or calluses)
- Immunosuppression (to include immunosuppressive medications or conditions as judged by the physician evaluating the patient at the baseline visit).
- Allergy to sesame oil
Data sourced from ClinicalTrials.gov (NCT04278573). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.