Early Phase 1
Completed N=8
Neurobehavioral Mechanisms of Cocaine Choice
Source: ClinicalTrials.gov NCT04296006 ↗Enrolled (actual)
8
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcomePrimary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 110; 98; 90 number of choices
Summary
The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during a behavioral intervention (alternative money reinforcer) that models contingency management.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative |
110; 98; 90 | — |
Eligibility Criteria
Inclusion Criteria
- Recent cocaine use, otherwise healthy
Exclusion Criteria
- Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
Data sourced from ClinicalTrials.gov (NCT04296006). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.