Early Phase 1
N=8
Neurobehavioral Mechanisms of Cocaine Choice
Cocaine Use Disorder
Bottom Line
View on ClinicalTrials.gov: NCT04296006 ↗Enrolled (actual)
8
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcome: Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 110; 98; 90 number of choices
Study Design & Population
- Study type
- Interventional
- Phase
- Early Phase 1
- Interventions
- Money (Behavioral); Cocaine HCl (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Joshua A. Lile, Ph.D.
- Primary completion
- Feb 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative |
110; 98; 90 | — |
Summary
The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during a behavioral intervention (alternative money reinforcer) that models contingency management.
Eligibility Criteria
Inclusion Criteria
- Recent cocaine use, otherwise healthy
Exclusion Criteria
- Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
Data sourced from ClinicalTrials.gov (NCT04296006). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.